INT219419

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Context Info
Confidence 0.23
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.11
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDK2, E2F2) nucleus (CDK2, E2F2) endosome (CDK2)
DNA binding (E2F2) cytoplasm (CDK2) cytosol (CDK2)
CDK2 (Homo sapiens)
E2F2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 3 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 30 56.32 Quite High
Stress 30 50.84 Quite High
Breast Cancer 11 50.00 Quite Low
Hypoxia 17 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Adenocarcinoma 3 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low
Hyperplasia 2 5.00 Very Low Very Low Very Low
Starvation 2 5.00 Very Low Very Low Very Low
Hepatocellular Cancer 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes, whose products are involved in the transition from G1 to S-phase appeared to be downregulated, such as cyclins (CCNA2, CCNE2, CCNF), cyclin-dependent kinase 2 (CDK2) and transcription regulators (E2F2, PCNA, SKP2), whereas transcription of inhibitory genes cyclin G2 (CCNG2), GADD45A (growth arrest and DNA-damage-inducible, alpha) and p21cip1 (cyclin-dependent kinase inhibitor 1A, CDKN1A) was increased.
CDK2 Regulation (regulators) of E2F2
1) Confidence 0.23 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.11 Pain Relevance 0

General Comments

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