INT219423

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Context Info
Confidence 0.24
First Reported 2007
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.46
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (AHR, ARNT) signal transducer activity (AHR, ARNT) nucleus (AHR, ARNT)
transcription factor binding (AHR, ARNT) cell differentiation (ARNT) immune system process (AHR)
Anatomy Link Frequency
macrophages 2
AHR (Homo sapiens)
ARNT (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 9 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Dismenorea 3 5.00 Very Low Very Low Very Low
Dopamine 3 5.00 Very Low Very Low Very Low
Rheumatism 3 5.00 Very Low Very Low Very Low
nud 3 5.00 Very Low Very Low Very Low
Serotonin 3 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mycobacterial Infection 162 83.92 Quite High
Breast Cancer 33 50.00 Quite Low
Infection 22 49.96 Quite Low
Apoptosis 90 46.08 Quite Low
Laboratory Infection 2 43.12 Quite Low
Sprains And Strains 36 41.80 Quite Low
Hepatocellular Cancer 3 29.60 Quite Low
Stress 90 22.08 Low Low
Cancer 21 15.60 Low Low
Disease 14 11.52 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The AhR, upon binding of a ligand, forms a heterodimeric complex with ARNT (aryl hydrocarbon receptor nuclear translocator) which induces transactivation of the CYPs and other target genes via binding to xenobiotic response elements (XREs) in their promoter regions [63].
AhR Binding (forms) of ARNT
1) Confidence 0.24 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0 Pain Relevance 0
The AhR, upon binding of a ligand, forms a heterodimeric complex with ARNT (aryl hydrocarbon receptor nuclear translocator) which induces transactivation of the CYPs and other target genes via binding to xenobiotic response elements (XREs) in their promoter regions [63].
AhR Binding (binding) of ARNT
2) Confidence 0.18 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0 Pain Relevance 0
The AhR, upon binding of a ligand, forms a heterodimeric complex with ARNT (aryl hydrocarbon receptor nuclear translocator) which induces transactivation of the CYPs and other target genes via binding to xenobiotic response elements (XREs) in their promoter regions [63].
AhR Binding (complex) of ARNT
3) Confidence 0.18 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0 Pain Relevance 0
This suggests that an unaffected AHR/ARNT transcription factor complex that is likely to occur in the IRGM wild-type gene promoter, may decrease innate immune responses mediated by macrophages.
AHR Binding (complex) of ARNT in macrophages
4) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.23 Pain Relevance 0
This suggests that an unaffected AHR/ARNT transcription factor complex that is likely to occur in the IRGM wild-type gene promoter, may decrease innate immune responses mediated by macrophages.
AHR Binding (complex) of ARNT in macrophages
5) Confidence 0.01 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2735778 Disease Relevance 0.23 Pain Relevance 0

General Comments

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