INT21944

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Context Info
Confidence 0.34
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 0.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1a, Gnrh1) extracellular region (Il1a, Gnrh1) cytosol (Il1a)
molecular_function (Gnrh1)
Anatomy Link Frequency
neuronal 1
Il1a (Rattus norvegicus)
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cytokine 6 98.20 Very High Very High Very High
Endogenous opioid 6 97.76 Very High Very High Very High
Opioid 3 75.36 Quite High
narcan 6 64.72 Quite High
antagonist 3 64.36 Quite High
opiate 3 63.92 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that IL-1 alpha and IL-1 beta inhibit LHRH-LH release by stimulating the activity of hypothalamic endogenous opioid peptide systems.
IL-1 Negative_regulation (inhibit) of LHRH associated with endogenous opioid
1) Confidence 0.34 Published 1990 Journal Endocrinology Section Abstract Doc Link 2226323 Disease Relevance 0 Pain Relevance 0.35
These results suggest that IL-1 alpha and IL-1 beta inhibit LHRH-LH release by stimulating the activity of hypothalamic endogenous opioid peptide systems.
IL-1 alpha Negative_regulation (inhibit) of LHRH associated with endogenous opioid
2) Confidence 0.34 Published 1990 Journal Endocrinology Section Abstract Doc Link 2226323 Disease Relevance 0 Pain Relevance 0.35
Whether IL-1 inhibits LHRH release by a direct action or via some other neuronal system is not known.
IL-1 Negative_regulation (inhibits) of LHRH in neuronal
3) Confidence 0.34 Published 1990 Journal Endocrinology Section Abstract Doc Link 2226323 Disease Relevance 0 Pain Relevance 0.19

General Comments

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