INT219458

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Context Info
Confidence 0.38
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 1.23
Pain Relevance 2.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CCNA2) mitosis (CCNA2) nucleus (CCNA2)
cell division (CCNA2) cytoplasm (CCNA2)
Anatomy Link Frequency
brains 1
neural 1
CCNA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 1460 99.88 Very High Very High Very High
Central nervous system 50 59.48 Quite High
monoamine 15 5.00 Very Low Very Low Very Low
antagonist 14 5.00 Very Low Very Low Very Low
Neurotransmitter 13 5.00 Very Low Very Low Very Low
Spinal cord 12 5.00 Very Low Very Low Very Low
cerebral cortex 10 5.00 Very Low Very Low Very Low
Neurobehavioral 10 5.00 Very Low Very Low Very Low
Dopamine 8 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 86 97.76 Very High Very High Very High
Cytomegalovirus Infection 20 91.48 High High
Neurodegenerative Disease 111 84.00 Quite High
Death 46 66.56 Quite High
Apoptosis 109 59.52 Quite High
Stress 227 54.04 Quite High
Breast Cancer 33 50.00 Quite Low
Intellectual Impairment 5 36.36 Quite Low
Cocaine Dependence 35 28.16 Quite Low
Hyperplasia 11 27.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes, whose products are involved in the transition from G1 to S-phase appeared to be downregulated, such as cyclins (CCNA2, CCNE2, CCNF), cyclin-dependent kinase 2 (CDK2) and transcription regulators (E2F2, PCNA, SKP2), whereas transcription of inhibitory genes cyclin G2 (CCNG2), GADD45A (growth arrest and DNA-damage-inducible, alpha) and p21cip1 (cyclin-dependent kinase inhibitor 1A, CDKN1A) was increased.
Negative_regulation (downregulated) of CCNA2
1) Confidence 0.38 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.11 Pain Relevance 0
Elevated levels of CCNG2, cyclin B1 interacting protein 1 (CCNB1IP1), forkhead box O3A (FOXO3A), GADD45A and p21cip1 genes as well as downregulation of cyclin A2 (CCNA2) and CDK2 provided evidence that cell cycle progression might be additionally arrested at the G2/M-checkpoint.
Negative_regulation (downregulation) of cyclin A2
2) Confidence 0.38 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.05 Pain Relevance 0
Elevated levels of CCNG2, cyclin B1 interacting protein 1 (CCNB1IP1), forkhead box O3A (FOXO3A), GADD45A and p21cip1 genes as well as downregulation of cyclin A2 (CCNA2) and CDK2 provided evidence that cell cycle progression might be additionally arrested at the G2/M-checkpoint.
Negative_regulation (downregulation) of CCNA2
3) Confidence 0.38 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.05 Pain Relevance 0
Quantitative real-time RT-PCR showed that cyclin A2 mRNA was decreased as early as 6 h after 10 or 100 ?
Negative_regulation (decreased) of cyclin A2
4) Confidence 0.28 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.22 Pain Relevance 0.43
Cocaine also decreased cyclin A2 levels in neural progenitor cells freshly isolated from human fetal brains and in fetal rat brains exposed to the drug while in their mother's womb.
Negative_regulation (decreased) of cyclin A2 in neural associated with cocaine
5) Confidence 0.28 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.37
Other experiments indicate that the reduction of cyclin A2 by cocaine in AF5 cells involves the accumulation of “reactive oxygen species,” by-products of the breakdown of cocaine by a protein that is a member of a family of proteins called cytochrome P450.
Negative_regulation (reduction) of cyclin A2 associated with cocaine
6) Confidence 0.28 Published 2008 Journal PLoS Medicine Section Abstract Doc Link PMC2504032 Disease Relevance 0 Pain Relevance 0.38
Cocaine causes specific down-regulation of cyclin A2 in AF5 cells, primary neural and A2B5+ progenitor cells, and fetal brains exposed to cocaine in utero.
Negative_regulation (down-regulation) of cyclin A2 in brains associated with cocaine
7) Confidence 0.28 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.18 Pain Relevance 0.62
M, 24 h) decreases cyclin A2 protein in AF5 cells (Figure 5A).
Negative_regulation (decreases) of cyclin A2
8) Confidence 0.27 Published 2008 Journal PLoS Medicine Section Body Doc Link PMC2504032 Disease Relevance 0.15 Pain Relevance 0.41
The attenuation of cell proliferation by Rex1 inhibition was attended by the downregulation of CDK2, CDK4, and Cyclin 2 (Figure 3C).
Negative_regulation (downregulation) of Cyclin 2
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.45 Pain Relevance 0

General Comments

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