INT21947

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Context Info
Confidence 0.48
First Reported 1990
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il1a, Pomc) extracellular region (Il1a, Pomc) cell-cell signaling (Pomc)
cytoplasm (Pomc) cytosol (Il1a) generation of precursor metabolites and energy (Pomc)
Il1a (Rattus norvegicus)
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 1 92.80 High High
cytokine 2 84.48 Quite High
Endogenous opioid 2 75.00 Quite High
opiate 1 55.36 Quite High
antagonist 1 54.80 Quite High
narcan 2 53.92 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since IL-1 reportedly stimulates the release of POMC peptides, which are known to be inhibitory to the LHRH-LH axis, we have tested the hypothesis that the inhibitory influence of IL-1 may be mediated via activation of hypothalamic opioid peptides.
IL-1 Positive_regulation (stimulates) of Localization (release) of POMC associated with opioid
1) Confidence 0.48 Published 1990 Journal Endocrinology Section Abstract Doc Link 2226323 Disease Relevance 0 Pain Relevance 0.32

General Comments

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