INT219470

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.83
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (FOXO3) embryo development (FOXO3) DNA binding (FOXO3)
response to stress (FOXO3) cytoplasm (FOXO3) cytosol (FOXO3)
Anatomy Link Frequency
cardiovascular system 1
FOXO3 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 1 68.88 Quite High
Pain 3 57.12 Quite High
Glutamate 1 26.32 Quite Low
Central nervous system 21 5.00 Very Low Very Low Very Low
cINOD 4 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
cva 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Bioavailability 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 91 98.96 Very High Very High Very High
Cancer 147 92.40 High High
Stress 40 89.44 High High
Hyperplasia 8 88.96 High High
Glioma 78 87.40 High High
Breast Cancer 27 87.32 High High
Necrosis 1 84.72 Quite High
Aging 2 75.28 Quite High
Disease 45 72.00 Quite High
Colon Cancer 6 57.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because it is known that exercise training exerts its beneficial effects particularly on the cardiovascular system, we tested FOXO3A and its targets involvement in group, showing that exercise training enhanced FOXO3A RNA levels.
Positive_regulation (enhanced) of FOXO3A in cardiovascular system
1) Confidence 0.61 Published 2010 Journal BMC Physiol Section Body Doc Link PMC2893521 Disease Relevance 0.48 Pain Relevance 0
FOXO3A, GADD45A, GDF 15 (growth differentiation factor 15) and p21cip1, whose mRNA levels increased, are also connected with apoptosis in addition to their role in cell cycle control.
Positive_regulation (increased) of FOXO3A associated with apoptosis
2) Confidence 0.43 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 1.14 Pain Relevance 0
In the present study, we show that the co-depletion of cathepsin B and uPAR arrests cells in the G1 phase primarily through the upregulation of p27Kip1 and that this pathway involves the downregulation of p-PI3K, p-AKT, D-type cyclin expression, and cyclin E/Cdk2 complex formation as well as the subsequent upregulation of the FOXO3a protein and its nuclear localization.
Positive_regulation (upregulation) of FOXO3a
3) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0.54 Pain Relevance 0
Expression of p27Kip1 is influenced by the upregulation of FOXO3a proteins in cathepsin B and uPAR depleted cells
Positive_regulation (upregulation) of FOXO3a
4) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
We further analyzed the effect of upregulation of FOXO3a on p27Kip1 expression at the transcriptional level.
Positive_regulation (upregulation) of FOXO3a
5) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908539 Disease Relevance 0 Pain Relevance 0
Prolonged inhibition of ErbB2 kinase activity resulted in upregulation of the transcription factor FOXO3A which upregulates estrogen receptor (ER) expression and signaling.
Positive_regulation (upregulation) of FOXO3A
6) Confidence 0.17 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004582 Disease Relevance 0.66 Pain Relevance 0.18

General Comments

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