INT219492

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.74
Pain Relevance 1.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CDC6) nucleoplasm (CDC6) mitosis (CDC6)
nucleus (CDC6) cell division (CDC6) cytoplasm (CDC6)
Anatomy Link Frequency
H69 1
CDC6 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 260 99.76 Very High Very High Very High
Pain 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
Neurotransmitter 1 5.00 Very Low Very Low Very Low
Dismenorea 1 5.00 Very Low Very Low Very Low
Dopamine 1 5.00 Very Low Very Low Very Low
Rheumatism 1 5.00 Very Low Very Low Very Low
nud 1 5.00 Very Low Very Low Very Low
Serotonin 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Small Cell Lung Cancer 126 99.34 Very High Very High Very High
Cancer 91 88.76 High High
Apoptosis 42 73.52 Quite High
Disease 6 64.80 Quite High
Lung Cancer 21 57.00 Quite High
Breast Cancer 15 56.80 Quite High
Hyperplasia 2 47.60 Quite Low
Metastasis 6 31.84 Quite Low
Stress 30 27.72 Quite Low
Non-small-cell Lung Cancer 4 26.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The treatment of H69 human SCLC cells with capsaicin leads to a switch in E2F subtypes on cyclin E, TS, cdc25A and cdc6 promoters; E2F1–3 are dissociated from the promoter, and E2F4 and p130 are recruited.
Negative_regulation (switch) of cdc6 in H69 associated with qutenza and small cell lung cancer
1) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2857654 Disease Relevance 0.71 Pain Relevance 0.40
The level of various DNA replication related genes (CDC6, CDT1, FEN1, MCM2, MCM3, MCM4, MCM5, MCM7, MCM10, Pfs2, RFC3) was also reduced, thereby suggesting a reduction in the replication rate.
Negative_regulation (reduced) of CDC6
2) Confidence 0.14 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0.36 Pain Relevance 0
We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.
Negative_regulation (decrease) of cdc6 associated with qutenza
3) Confidence 0.09 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2857654 Disease Relevance 0.67 Pain Relevance 0.91

General Comments

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