INT21950

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Context Info
Confidence 0.44
First Reported 1987
Last Reported 1990
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 0.81
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein folding (Ahsp) cytoplasm (Ahsp)
Anatomy Link Frequency
endothelial cells 2
endothelium 2
epithelium 2
Ahsp (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 14 98.98 Very High Very High Very High
Angina 2 98.52 Very High Very High Very High
agonist 10 96.48 Very High Very High Very High
antagonist 2 94.92 High High
Serotonin 2 78.40 Quite High
bradykinin 1 66.32 Quite High
addiction 1 51.52 Quite High
anesthesia 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Myocardial Infarction 1 99.24 Very High Very High Very High
Hypotension 4 98.72 Very High Very High Very High
Cv General 3 Under Development 2 98.52 Very High Very High Very High
Increased Venous Pressure Under Development 3 75.00 Quite High
Adhesions 1 73.76 Quite High
Thrombosis 1 71.68 Quite High
Hypertension 1 36.40 Quite Low
Diabetes Mellitus 1 35.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our results suggest instead that this endothelium-dependent inhibition is due to spontaneous release of EDRF, which results in tonic elevation of cGMP in the vascular smooth muscle.
Positive_regulation (due) of Localization (release) of EDRF in endothelium
1) Confidence 0.44 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2885738 Disease Relevance 0 Pain Relevance 0.52
Endothelium-derived relaxing factors (EDRFs) have been previously shown to exert an inhibitory influence on the contractile effects of alpha-adrenoceptor agonists in vascular smooth muscle. alpha 2-Adrenoceptor agonists such as clonidine have been reported to be particularly susceptible to this effect, and it has been suggested that clonidine acts on alpha 2 receptors on endothelial cells to stimulate the release of EDRF.
Positive_regulation (stimulate) of Localization (release) of EDRF in endothelial cells associated with agonist and clonidine
2) Confidence 0.44 Published 1987 Journal Mol. Pharmacol. Section Abstract Doc Link 2885738 Disease Relevance 0 Pain Relevance 0.37
If a vasodilator induces release of EDRF from the epithelium it is classified as endothelium-dependent, if not it is independent.
Positive_regulation (induces) of Localization (release) of EDRF in epithelium
3) Confidence 0.35 Published 1989 Journal Ann Cardiol Angeiol (Paris) Section Abstract Doc Link 2629613 Disease Relevance 0.25 Pain Relevance 0.19
Thus, a stimulation of EDRF release contributes to the LPS-induced hypotension in the anaesthetized rat.
Positive_regulation (stimulation) of Localization (release) of EDRF associated with hypotension
4) Confidence 0.32 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2226626 Disease Relevance 0.26 Pain Relevance 0
This, in turn, stimulates EDRF (NO) release in epicardial arteries and dilation.
Positive_regulation (stimulates) of Localization (release) of EDRF
5) Confidence 0.23 Published 1988 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154691 Disease Relevance 0.29 Pain Relevance 0.20

General Comments

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