INT219505

Context Info Confidence 0.50 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0

isomerase activity (Ppib) cell differentiation (ARNT) endoplasmic reticulum (Ppib) cytoplasm (ARNT) signal transducer activity (ARNT) protein folding (Ppib)

ARNT (Homo sapiens) Ppib (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 3 5.00 Neurotransmitter 1 5.00 Pain 1 5.00 Dismenorea 1 5.00 Dopamine 1 5.00 Rheumatism 1 5.00 nud 1 5.00 Serotonin 1 5.00

Disease Link Frequency Relevance Heat Breast Cancer 11 50.00 Apoptosis 30 43.44 Hepatocellular Cancer 1 26.80 Stress 30 19.44 Cancer 7 12.96 Hypoxia 17 5.00 Adenocarcinoma 3 5.00 Metastasis 2 5.00 Hyperplasia 2 5.00 Starvation 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The AhR, upon binding of a ligand, forms a heterodimeric complex with ARNT (aryl hydrocarbon receptor nuclear translocator) which induces transactivation of the CYPs and other target genes via binding to xenobiotic response elements (XREs) in their promoter regions [63].

ARNT Positive_regulation (induces) of Positive_regulation (transactivation) of CYPs

1) Confidence 0.50 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0 Pain Relevance 0

General Comments

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