INT21952

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Context Info
Confidence 0.78
First Reported 1990
Last Reported 2010
Negated 2
Speculated 1
Reported most in Abstract
Documents 42
Total Number 43
Disease Relevance 20.32
Pain Relevance 9.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (GDNF) extracellular region (GDNF)
Anatomy Link Frequency
glial cell 5
brain 3
neural 3
striatum 2
spinal cord 2
GDNF (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 65 100.00 Very High Very High Very High
Pain 59 99.64 Very High Very High Very High
neuralgia 7 99.56 Very High Very High Very High
antiallodynic 12 99.48 Very High Very High Very High
Neuropathic pain 29 98.92 Very High Very High Very High
Sciatica 9 98.88 Very High Very High Very High
Spinal cord 97 98.64 Very High Very High Very High
dorsal root ganglion 4 98.64 Very High Very High Very High
Morphine 3 97.44 Very High Very High Very High
Dorsal horn 10 97.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cold Sores 750 99.84 Very High Very High Very High
Lung Cancer 56 99.84 Very High Very High Very High
Pain 56 99.56 Very High Very High Very High
Cancer 574 99.28 Very High Very High Very High
Neuropathic Pain 44 98.92 Very High Very High Very High
Neuroma 7 98.92 Very High Very High Very High
Ganglion Cysts 9 98.64 Very High Very High Very High
Disease 402 98.28 Very High Very High Very High
Hydrocephalus 1 98.24 Very High Very High Very High
Pancreatic Cancer 60 97.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used immunohistochemical staining to assess protein over-expression of glial cell-derived neurotrophic factor (GDNF) and its RET receptor tyrosine kinase in patients with pancreatic cancer and benign pancreatic neoplasm, and assessed correlations with clinicopathological features and prognosis.
Gene_expression (expression) of GDNF in glial cell associated with pancreatic cancer
1) Confidence 0.78 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.54 Pain Relevance 0.05
Intrapancreatic neural invasion by cancer cells was significantly related to over-expression of GDNF.
Gene_expression (over) of GDNF in neural associated with cancer
2) Confidence 0.78 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.92 Pain Relevance 0.09
We used immunohistochemical staining to assess protein over-expression of glial cell-derived neurotrophic factor (GDNF) and its RET receptor tyrosine kinase in patients with pancreatic cancer and benign pancreatic neoplasm, and assessed correlations with clinicopathological features and prognosis.
Gene_expression (expression) of glial cell-derived neurotrophic factor in glial cell associated with pancreatic cancer
3) Confidence 0.78 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.54 Pain Relevance 0.05
Strongly positive expression of GDNF may be an indication for early intensified radiotherapy.
Gene_expression (expression) of GDNF
4) Confidence 0.78 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.90 Pain Relevance 0.09
Strongly positive expression of GDNF was significantly more frequent than lesser grades of expression in patients with severe back pain before and 12 months after surgery.
Gene_expression (expression) of GDNF associated with backache
5) Confidence 0.78 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.93 Pain Relevance 0.10
To examine whether HSV-mediated expression of GDNF could be used to ameliorate neuropathic pain, we constructed a replication-incompetent HSV vector expressing GDNF.
Gene_expression (expression) of GDNF associated with cold sores and neuropathic pain
6) Confidence 0.78 Published 2003 Journal Mol. Ther. Section Abstract Doc Link 12946309 Disease Relevance 1.08 Pain Relevance 0.86
Vector-mediated GDNF expression blocked the nonnoxious touch-induced increase in c-fos expression in dorsal horn characteristic of the painful state.
Gene_expression (expression) of GDNF in dorsal horn associated with pain and dorsal horn
7) Confidence 0.78 Published 2003 Journal Mol. Ther. Section Abstract Doc Link 12946309 Disease Relevance 0.91 Pain Relevance 0.92
Quantitative RT-PCR analysis revealed no significant differences in the expression of neurotrophic factors, brain-derived neurotrophic factor (BDNF);glial-derived neurotrophic factor (GDNF) and cAMP-responsive element-binding protein (CREB) between cells treated with fluoxetine for two weeks and their untreated counterparts.
Gene_expression (expression) of GDNF in brain associated with fluoxetine
8) Confidence 0.76 Published 2010 Journal Int. J. Dev. Biol. Section Abstract Doc Link 19598107 Disease Relevance 0.17 Pain Relevance 0.88
As in primary human MSCs, B10 cells express high levels of NGF, BDNF, CNTF, GDNF, bFGF, IGF-I, HGF and VEGF (Figure 10).
Gene_expression (express) of GDNF in HGF
9) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.25 Pain Relevance 0.20
Our RT-PCR studies show that B10 human MSCs as in primary human MSCs express BDNF, GDNF, CNTF, bFGF, VEGF, HGF and IGF that may work as neuroprotective factors in the ICH mice.
Gene_expression (express) of GDNF in HGF associated with cva
10) Confidence 0.75 Published 2007 Journal PLoS ONE Section Body Doc Link PMC2092394 Disease Relevance 0.63 Pain Relevance 0.12
The common receptor for GDNF family ligands, Ret, is highly expressed in nonpeptidergic neurons, but its function during development of these neurons is unclear.
Gene_expression (expressed) of GDNF in neurons
11) Confidence 0.75 Published 2007 Journal Neuron Section Abstract Doc Link 17553423 Disease Relevance 0 Pain Relevance 0
We have demonstrated that systemic administration of dipeptide Leu-Ile increases BDNF and GDNF production in the brain, and has a protective role in methamphetamine and morphine dependence.
Gene_expression (production) of GDNF in brain associated with addiction and morphine
12) Confidence 0.75 Published 2009 Journal Nihon Shinkei Seishin Yakurigaku Zasshi Section Abstract Doc Link 19562947 Disease Relevance 0.49 Pain Relevance 0.18
Neuroregenerative effects of lentiviral vector-mediated GDNF expression in reimplanted ventral roots.
Gene_expression (expression) of GDNF in ventral roots associated with sciatica
13) Confidence 0.74 Published 2008 Journal Mol. Cell. Neurosci. Section Title Doc Link 18585464 Disease Relevance 0.25 Pain Relevance 0.20
However, over the course of 16 weeks neuroma-like structures are formed in the reimplanted roots, and regenerating axons are trapped at sites with high levels of GDNF expression.
Gene_expression (expression) of GDNF associated with neuroma
14) Confidence 0.74 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18585464 Disease Relevance 0.26 Pain Relevance 0
To examine whether HSV-mediated expression of GDNF could be used to ameliorate neuropathic pain, we constructed a replication-incompetent HSV vector expressing GDNF.
Gene_expression (expressing) of GDNF associated with cold sores and neuropathic pain
15) Confidence 0.68 Published 2003 Journal Mol. Ther. Section Abstract Doc Link 12946309 Disease Relevance 1.05 Pain Relevance 0.92
Quantitative RT-PCR analysis revealed no significant differences in the expression of neurotrophic factors, brain-derived neurotrophic factor (BDNF);glial-derived neurotrophic factor (GDNF) and cAMP-responsive element-binding protein (CREB) between cells treated with fluoxetine for two weeks and their untreated counterparts.
Gene_expression (expression) of glial-derived neurotrophic factor in brain associated with fluoxetine
16) Confidence 0.67 Published 2010 Journal Int. J. Dev. Biol. Section Abstract Doc Link 19598107 Disease Relevance 0.17 Pain Relevance 0.87
NGF and glial cell line-derived neurotrophic factor (GDNF) are both produced by basal keratinocytes and neurotrophin (NT-3) by suprabasal keratinocytes: relative mRNA expression was significantly lower in early diabetic neuropathy skin compared to controls, for NGF (P < 0.02), BDNF (P < 0.05), NT-3 (P < 0.05), GDNF (< 0.02), but not NT4/5, Trk A or p75 neurotrophin receptor (all P > 0.05).
Gene_expression (produced) of glial cell line-derived neurotrophic factor in keratinocytes associated with nerve growth factor, trk a and diabetic neuropathy
17) Confidence 0.66 Published 2004 Journal Prog. Brain Res. Section Abstract Doc Link 14699981 Disease Relevance 1.34 Pain Relevance 0.96
Here, we show in a rat model that lentiviral vector-mediated overexpression of glial cell line-derived neurotrophic factor (GDNF) in reimplanted nerve roots completely prevents motoneuron atrophy after ventral root avulsion and stimulates regeneration of axons into reimplanted roots.
Gene_expression (overexpression) of GDNF in glial cell associated with frailty
18) Confidence 0.64 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18585464 Disease Relevance 0.27 Pain Relevance 0
Receptors for NGF and GDNF are highly expressed in human peripheral nerve neuroma.
Gene_expression (expressed) of GDNF in peripheral nerve associated with neuralgia and neuroma
19) Confidence 0.61 Published 2002 Journal Muscle Nerve Section Title Doc Link 11932982 Disease Relevance 0.36 Pain Relevance 0.35
Intrapancreatic neural invasion by cancer cells was significantly related to over-expression of GDNF.
Gene_expression (-) of GDNF in neural associated with cancer
20) Confidence 0.60 Published 2008 Journal J. Int. Med. Res. Section Abstract Doc Link 18652760 Disease Relevance 0.92 Pain Relevance 0.09

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