INT21956

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Context Info
Confidence 0.34
First Reported 1990
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 13
Disease Relevance 7.32
Pain Relevance 5.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Mmp7) extracellular region (Mmp7) proteinaceous extracellular matrix (Mmp7)
Anatomy Link Frequency
joint 1
plasma 1
smooth muscle 1
brain 1
Mmp7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 178 100.00 Very High Very High Very High
anesthesia 12 99.64 Very High Very High Very High
opioid receptor 1 99.36 Very High Very High Very High
Pain 127 99.04 Very High Very High Very High
ischemia 61 98.12 Very High Very High Very High
Chronic pancreatitis 8 98.08 Very High Very High Very High
antagonist 6 98.08 Very High Very High Very High
Osteoarthritis 99 97.68 Very High Very High Very High
Neurotransmitter 2 96.60 Very High Very High Very High
cytokine 10 95.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypertension 15 99.76 Very High Very High Very High
Brain Injury 2 99.20 Very High Very High Very High
Carcinoma 7 99.08 Very High Very High Very High
Pain 136 99.04 Very High Very High Very High
Hypoxia 52 98.44 Very High Very High Very High
Immunization 15 98.20 Very High Very High Very High
Cv Unclassified Under Development 58 98.12 Very High Very High Very High
Pancreatitis 8 98.08 Very High Very High Very High
Osteoarthritis 99 97.68 Very High Very High Very High
Injury 78 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, plasma MMP-7 levels discriminated between patients with carcinoma and those with chronic pancreatitis or benign disease.
Negative_regulation (discriminated) of MMP-7 in plasma associated with carcinoma, disease and chronic pancreatitis
1) Confidence 0.34 Published 2007 Journal Cancer Epidemiol. Biomarkers Prev. Section Abstract Doc Link 17507610 Disease Relevance 0.93 Pain Relevance 0.32
In animals given phosphoramidon (0.25 mg/kg per min i.v.), a metalloproteinase inhibitor, the hypertensive effect of big endothelin-1 was markedly attenuated.
Negative_regulation (inhibitor) of metalloproteinase associated with hypertension and metalloproteinase
2) Confidence 0.22 Published 1990 Journal Eur. J. Pharmacol. Section Abstract Doc Link 2226629 Disease Relevance 0.36 Pain Relevance 0.13
Phosphoramidon, a metalloproteinase inhibitor, suppresses the hypertensive effect of big endothelin-1.
Negative_regulation (inhibitor) of metalloproteinase associated with anesthesia, hypertension and metalloproteinase
3) Confidence 0.22 Published 1990 Journal Eur. J. Pharmacol. Section Title Doc Link 2226629 Disease Relevance 0.36 Pain Relevance 0.23
Effects of a metalloproteinase inhibitor on osteochondral angiogenesis, chondropathy and pain behavior in a rat model of osteoarthritis
Negative_regulation (inhibitor) of metalloproteinase associated with pain, metalloproteinase and osteoarthritis
4) Confidence 0.09 Published 2010 Journal Osteoarthritis and Cartilage Section Title Doc Link PMC2853084 Disease Relevance 0.63 Pain Relevance 0.58
To investigate the effects of a matrix metalloproteinase (MMP) inhibitor on joint pathology and pain behavior in the rat meniscal transection (MNX) model of osteoarthritis (OA) and evaluate which aspects of structural disease modification contribute to symptom improvement.


Spec (investigate) Negative_regulation (inhibitor) of metalloproteinase in joint associated with pain, metalloproteinase, disease and osteoarthritis
5) Confidence 0.08 Published 2010 Journal Osteoarthritis and Cartilage Section Abstract Doc Link PMC2853084 Disease Relevance 0.64 Pain Relevance 0.53
Janusz et al10 demonstrated a reduction in chondropathy following MMP inhibition with an Matrix Metalloproteinase inhibitor (MMPi) inhibitor, structurally related to hydroxamic acid (Proctor and Gamble) in a meniscal injury model of OA.
Negative_regulation (inhibitor) of Metalloproteinase associated with injury, metalloproteinase and osteoarthritis
6) Confidence 0.08 Published 2010 Journal Osteoarthritis and Cartilage Section Body Doc Link PMC2853084 Disease Relevance 1.09 Pain Relevance 0.98
Partial sequence of the 88-kD protein indicates that it may be related to the inhibitor of metalloproteinase.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase
7) Confidence 0.05 Published 2004 Journal Front. Biosci. Section Abstract Doc Link 15353366 Disease Relevance 0 Pain Relevance 0.59
We did not observe any increased metalloproteinase or tissue inhibitors of metalloproteinases.
Negative_regulation (inhibitors) of metalloproteinase associated with metalloproteinase
8) Confidence 0.02 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2827566 Disease Relevance 0.48 Pain Relevance 0.19
Delayed administration of a matrix metalloproteinase inhibitor limits progressive brain injury after hypoxia-ischemia in the neonatal rat

Background

Negative_regulation (inhibitor) of metalloproteinase in brain associated with hypoxia, ischemia, metalloproteinase and brain injury
9) Confidence 0.01 Published 2008 Journal J Neuroinflammation Section Title Doc Link PMC2527306 Disease Relevance 1.23 Pain Relevance 0.60
The mRNA amount of procollagen alpha2(I), alpha-smooth muscle actin (alpha-SMA), tissue inhibitor of metalloproteinase (TIMP)-1, and TGF-beta1 was also increased by PDGF-BB.
Negative_regulation (inhibitor) of metalloproteinase in smooth muscle
10) Confidence 0.01 Published 2005 Journal Pancreas Section Body Doc Link 16025003 Disease Relevance 0 Pain Relevance 0
Furthermore antiangiogenic agents such as thalidomide [50], and a matrix metalloproteinase inhibitor [41] are reported to inhibit PRLoma growth based on a strategy to block angiogenesis.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase
11) Confidence 0.01 Published 2010 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC2875861 Disease Relevance 0.67 Pain Relevance 0.14
Multiple isoforms of matrix metalloproteinases (MMP) and tissue inhibitors of metalloproteinase are either up- or down regulated [35].
Negative_regulation (inhibitors) of metalloproteinase associated with metalloproteinase
12) Confidence 0.01 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.91 Pain Relevance 0.95
Some sections were incubated with 1 mM phenanthroline (Molecular Probes), a broad-spectrum metalloproteinase inhibitor.
Negative_regulation (inhibitor) of metalloproteinase associated with metalloproteinase
13) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3000320 Disease Relevance 0 Pain Relevance 0.11

General Comments

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