INT219565

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.50
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4d) Golgi apparatus (Pde4d) plasma membrane (Pde4d)
cytoskeleton (Pde4d) cytoplasm (Pde4d)
Pde4d (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 31 96.40 Very High Very High Very High
agonist 24 94.88 High High
Potency 5 79.36 Quite High
Inflammatory marker 4 75.92 Quite High
isoflurane 6 55.36 Quite High
anesthesia 2 54.16 Quite High
Inflammatory response 4 5.00 Very Low Very Low Very Low
chemokine 4 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pulmonary Disease 19 97.52 Very High Very High Very High
Asthma 4 97.00 Very High Very High Very High
INFLAMMATION 33 96.40 Very High Very High Very High
Pneumonia 7 50.00 Quite Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low
Hypertrophy 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low
Myocardial Infarction 4 5.00 Very Low Very Low Very Low
Vomiting 3 5.00 Very Low Very Low Very Low
Emphysema 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
l ProteinG Sepharose and the respective PDE4 subtype, or PDE4D splice variant antibodies, as well as IgG as a control.
Regulation (control) of PDE4D
1) Confidence 0.44 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.11
ARs is the effect of receptor occupancy on the PDE4D complexes.
Regulation (effect) of PDE4D
2) Confidence 0.44 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.12
We have developed FANA-modified antisenses oligonucleotides specifically targeting PDE isotypes 4B, 4D and 7A, as a potential new inhaled drug for the treatment of COPD.
Regulation (targeting) of 4D associated with pulmonary disease
3) Confidence 0.42 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.50 Pain Relevance 0.16

General Comments

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