INT219566

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.49
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Ryr2)
Ryr2 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 24 5.00 Very Low Very Low Very Low
isoflurane 6 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dilated Cardiomyopathy 2 94.76 High High
Hypertrophy 4 68.72 Quite High
Myocardial Infarction 4 67.44 Quite High
Apoptosis 4 5.00 Very Low Very Low Very Low
Adenovirus Infection 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Cytomegalovirus Infection 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lack of PDE4D causes PKA hyperphosphorylation of RyR2 and calstabin depletion from the channel, resulting in a ‘leaky' RyR2 channel phenotype that, in turn, may contribute to cardiac arrhythmias.
Localization (depletion) of RyR2
1) Confidence 0.45 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.28 Pain Relevance 0
PDE4D-deficiency in the cardiac ryanodine receptor/calcium release channel (RyR2) complex has been associated with this phenotype.
Localization (release) of RyR2
2) Confidence 0.39 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.21 Pain Relevance 0

General Comments

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