INT219579

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 9.07
Pain Relevance 1.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Twist1) nucleus (Twist1) DNA binding (Twist1)
transcription factor binding (Twist1)
Anatomy Link Frequency
Th1 cells 4
reticulum 2
Twist1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 193 100.00 Very High Very High Very High
Inflammatory mediators 9 97.80 Very High Very High Very High
Arthritis 45 90.56 High High
fibrosis 9 81.28 Quite High
isoflurane 3 80.08 Quite High
anesthesia 5 78.88 Quite High
Inflammatory stimuli 2 68.40 Quite High
cytokine 78 56.60 Quite High
chemokine 14 55.20 Quite High
metalloproteinase 43 38.56 Quite Low
Disease Link Frequency Relevance Heat
Cancer 295 100.00 Very High Very High Very High
INFLAMMATION 192 100.00 Very High Very High Very High
Age-related Macular Degeneration 53 99.74 Very High Very High Very High
Hyperplasia 13 98.76 Very High Very High Very High
Polyps 32 98.64 Very High Very High Very High
Stress 23 97.88 Very High Very High Very High
Death 44 97.84 Very High Very High Very High
Apoptosis 142 96.84 Very High Very High Very High
Frailty 3 96.72 Very High Very High Very High
Pulmonary Disease 88 95.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IL-4/STAT6 signaling could not suppress twist1 expression in residual IFN-?
Neg (not) Negative_regulation (suppress) of Gene_expression (expression) of twist1
1) Confidence 0.43 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0 Pain Relevance 0
Adoptive transfer of Th1 cells versus Th1 cells with a shRNA-mediated knockdown of twist1 expression demonstrates the relevance of twist1 expression by Th1 cells for the control of immunopathology.
Negative_regulation (knockdown) of Gene_expression (expression) of twist1 in Th1 cells
2) Confidence 0.42 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.69 Pain Relevance 0.32
When analyzed on day 21 after transfer, mice with a knockdown of twist1 expression in Th1 cells showed increased hyperplasia of the lining cells and synovial fibroblasts in the sublining layer, pannus formation, and vascularization.
Negative_regulation (knockdown) of Gene_expression (expression) of twist1 in Th1 cells associated with hyperplasia
3) Confidence 0.42 Published 2008 Journal The Journal of Experimental Medicine Section Body Doc Link PMC2525589 Disease Relevance 0.70 Pain Relevance 0.22
As shown in Figure 3B, the cytotoxicity of Pa-PDT was inhibited in the R-HepG2 cells when the cells were pre-treated with JNK inhibitor, where the cell viabilities could be restored to 80.5% and 48.5% in the 0.75 ?
Negative_regulation (inhibited) of Gene_expression (cytotoxicity) of Pa-PDT
4) Confidence 0.35 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.46 Pain Relevance 0
Furthermore, the cell viabilities decreased in a dose-dependent manner of Pa-PDT with IC50 value of 0.6 ?
Negative_regulation (decreased) of Gene_expression (manner) of Pa-PDT
5) Confidence 0.30 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2731730 Disease Relevance 0.89 Pain Relevance 0
EGFR expression analyzed using immunoblotting was found to be lower in the PDT plus Erbitux group (p < 0.001) compared to control, PDT only and Erbitux only groups (Figure 2).
Negative_regulation (lower) of Gene_expression (group) of PDT
6) Confidence 0.14 Published 2009 Journal Mol Cancer Section Body Doc Link PMC2777152 Disease Relevance 1.43 Pain Relevance 0
PDE4 and PDE3 activity are defined as the PDE activity inhibited by the PDE4-selective inhibitor, Rolipram (10 ?
Negative_regulation (defined) of Gene_expression (activity) of PDE
7) Confidence 0.11 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.16
The CFT significantly decreased not only in the PDT group but also in the s-IVB and m-IVB groups.
Negative_regulation (decreased) of Gene_expression (group) of PDT
8) Confidence 0.06 Published 2010 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2907029 Disease Relevance 1.19 Pain Relevance 0
In the recent past, intravitreal injection of triamcinolone acetonide (IVTA) has been used extensively as an adjunct to PDT in AMD in order to reduce the number of PDT sessions and evaluate possible beneficial effects on vision.
Negative_regulation (reduce) of Gene_expression (sessions) of PDT associated with age-related macular degeneration
9) Confidence 0.05 Published 2007 Journal Indian Journal of Ophthalmology Section Body Doc Link PMC2635983 Disease Relevance 0.48 Pain Relevance 0.03
In the recent past, intravitreal injection of triamcinolone acetonide (IVTA) has been used extensively as an adjunct to PDT in AMD in order to reduce the number of PDT sessions and evaluate possible beneficial effects on vision.
Negative_regulation (reduce) of Gene_expression (sessions) of PDT associated with age-related macular degeneration
10) Confidence 0.05 Published 2007 Journal Indian Journal of Ophthalmology Section Abstract Doc Link PMC2635983 Disease Relevance 0.52 Pain Relevance 0
Buytaert, et al. proposed that during PDT with hypericin occurs loss of the native SERCA2 protein levels and consequent endoplasmic reticulum Ca2+ depletion which causes disruption of Ca2+ homeostasis and cell death.
Negative_regulation (loss) of Gene_expression (depletion) of PDT in reticulum associated with cancer and death
11) Confidence 0.05 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2852855 Disease Relevance 1.21 Pain Relevance 0
Inhibitors of phosphodiesterase E4 (PDE4), the major PDE isoenzyme in inflammatory cells, decrease inflammatory cell migration, activation, and release of proteinases in vitro.
Negative_regulation (decrease) of Gene_expression (isoenzyme) of PDE associated with inflammation
12) Confidence 0.03 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629972 Disease Relevance 1.50 Pain Relevance 0.63

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