INT219580

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Context Info
Confidence 0.73
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 2.07
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4d) Golgi apparatus (Pde4d) plasma membrane (Pde4d)
cytoskeleton (Pde4d) cytoplasm (Pde4d)
Pde4d (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 93 92.08 High High
chemokine 12 91.04 High High
Inflammatory response 12 82.48 Quite High
Inflammatory mediators 3 68.76 Quite High
agonist 48 47.20 Quite Low
Potency 15 5.00 Very Low Very Low Very Low
Inflammatory marker 12 5.00 Very Low Very Low Very Low
isoflurane 12 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
anesthesia 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 15 98.64 Very High Very High Very High
Dilated Cardiomyopathy 4 97.12 Very High Very High Very High
Pneumonia 21 92.08 High High
INFLAMMATION 99 82.48 Quite High
Pulmonary Disease 57 79.76 Quite High
Hypertrophy 8 57.36 Quite High
Myocardial Infarction 8 56.08 Quite High
Asthma 12 5.00 Very Low Very Low Very Low
Vomiting 9 5.00 Very Low Very Low Very Low
Emphysema 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to controlling basal cAMP accumulation, targeting of PDE4D to the ?
Localization (targeting) of PDE4D
1) Confidence 0.73 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
PDE4D-deficiency in the cardiac ryanodine receptor/calcium release channel (RyR2) complex has been associated with this phenotype.
Localization (release) of PDE4D-deficiency
2) Confidence 0.73 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.21 Pain Relevance 0
The dynamic localization of different PDE4D splicing variants that we report, as well as their phosphorylation state, likely play a major role in controlling cAMP accumulation in this submembrane space.
Localization (localization) of PDE4D
3) Confidence 0.73 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.07 Pain Relevance 0
The fate and function of the released PDE4D are to be determined and may provide a means to regulate a distinct pool of cAMP away from the membrane.
Localization (released) of PDE4D
4) Confidence 0.73 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
The strong inhibitory activity of combined 4B/4D and 7A AONs on IL-8 and MCP-1 secretion is in line with their ability to knock down their respective target mRNA (Figure 1).


Localization (secretion) of 4D associated with targeted disruption
5) Confidence 0.58 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.45 Pain Relevance 0.16
One lead sequence specific for both mouse PDE4B and 4D mRNAs (AON 4B/4D), and one for mouse PDE7A (AON 7A) were selected, as well as control sequences, and used for all in vivo experiments.
Localization (specific) of 4D
6) Confidence 0.51 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.66 Pain Relevance 0.24
One lead sequence specific for both mouse PDE4B and 4D mRNAs (AON 4B/4D), and one for mouse PDE7A (AON 7A) were selected, as well as control sequences, and used for all in vivo experiments.
Localization (specific) of 4D
7) Confidence 0.51 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.67 Pain Relevance 0.24

General Comments

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