INT219581

Context Info Confidence 0.27 First Reported 2008 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 3 Disease Relevance 4.54 Pain Relevance 0

transport (Ryr2)

Ryr2 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 14 5.00 Catecholamine 6 5.00 ketamine 4 5.00 fibrosis 4 5.00 anesthesia 3 5.00 isoflurane 3 5.00 addiction 1 5.00 imagery 1 5.00

Disease Link Frequency Relevance Heat Double Outlet Right Ventricle 2 95.76 Dilated Cardiomyopathy 3 94.64 Ventricular Heart Septal Defects 2 94.40 Myocardial Infarction 12 92.48 Disease 112 91.12 Targeted Disruption 30 87.60 Alzheimer's Dementia 12 77.28 Hypoxia 2 75.44 Diabetes Mellitus 6 75.08 Increased Venous Pressure Under Development 2 74.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

PS2 also play an important role in cardiac excitation-contraction coupling by interacting with ryanodine receptor type 2 (RyR2) [13].

RyR2 Binding (interacting) of

1) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 2.16 Pain Relevance 0

PS2 also play an important role in cardiac excitation-contraction coupling by interacting with ryanodine receptor type 2 (RyR2) [13].

ryanodine receptor type 2 Binding (interacting) of

2) Confidence 0.27 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2696039 Disease Relevance 2.16 Pain Relevance 0

PDE4D-deficiency in the cardiac ryanodine receptor/calcium release channel (RyR2) complex has been associated with this phenotype.

RyR2 Binding (associated) of

3) Confidence 0.19 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.21 Pain Relevance 0

General Comments

This test has worked.