INT219589

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Context Info
Confidence 0.47
First Reported 2008
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 13
Total Number 14
Disease Relevance 0.51
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4d) Golgi apparatus (Pde4d) plasma membrane (Pde4d)
cytoskeleton (Pde4d) cytoplasm (Pde4d)
Pde4d (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 156 98.80 Very High Very High Very High
Inflammatory mediators 1 92.20 High High
chemokine 4 73.44 Quite High
isoflurane 39 60.88 Quite High
Inflammatory response 4 53.72 Quite High
Inflammation 31 50.00 Quite Low
addiction 13 37.92 Quite Low
anesthesia 13 5.00 Very Low Very Low Very Low
imagery 13 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dilated Cardiomyopathy 13 97.12 Very High Very High Very High
INFLAMMATION 33 91.80 High High
Targeted Disruption 5 88.68 High High
Hypertrophy 26 60.80 Quite High
Myocardial Infarction 26 59.52 Quite High
Pulmonary Disease 19 54.04 Quite High
Pneumonia 7 50.00 Quite Low
Apoptosis 26 5.00 Very Low Very Low Very Low
Stress 13 5.00 Very Low Very Low Very Low
Adenovirus Infection 13 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1AR efficiently interacts with PDE4D, whereas ?
PDE4D Binding (interacts) of
1) Confidence 0.47 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.11
PDE4D-deficiency in the cardiac ryanodine receptor/calcium release channel (RyR2) complex has been associated with this phenotype.
PDE4D-deficiency Binding (associated) of
2) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0.22 Pain Relevance 0
In this paradigm, PDE4D shows robust association with ?
PDE4D Binding (association) of
3) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.07
These findings suggest a function of PDE4D in complex with the ?
PDE4D Binding (function) of
4) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.11
1AR/PDE4D complex, HEK293 cells expressing exogenous ?
PDE4D Binding (complex) of
5) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.09
2AR has negligible affinity for PDE4D, underscoring the direct mode of PDE4D–?
PDE4D Binding (affinity) of
6) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.11
-arrestin/PDE4D complex to the receptor.
PDE4D Binding (complex) of
7) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.12
We propose that these divergent interactions with PDE4D variants specify the property of the signals emanating from the two receptors.
PDE4D Binding (interactions) of
8) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.08
1AR/PDE4D complex is present in the absence of agonist and dissociates after receptor occupancy, whereas agonist binding to the ?
PDE4D Binding (complex) of associated with agonist
9) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.13
1AR causes dissociation of the complex, it is likely that the ligand-induced dissociation of PDE4D from the ?
PDE4D Spec (likely) Binding (dissociation) of
10) Confidence 0.36 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
The direct interaction of PDE4D with the receptor, however, opens additional possibilities for a function of PDE4D in the ?
PDE4D Binding (interaction) of
11) Confidence 0.35 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
More importantly, this approach clearly indicates that PDE4D binds directly to the ?
PDE4D Binding (binds) of
12) Confidence 0.35 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0.08
PDE4D binds directly to the ?
PDE4D Binding (binds) of
13) Confidence 0.35 Published 2008 Journal EMBO J Section Body Doc Link PMC2196435 Disease Relevance 0 Pain Relevance 0
Cells were transfected with a combination of 4B/4D and 7A AONs, each at 134 or 267 nM; cells were then stimulated and levels of IL-8 and MCP-1 produced were measured in cell culture supernatants by ELISA.
4D Binding (combination) of
14) Confidence 0.25 Published 2009 Journal Respir Res Section Body Doc Link PMC2696437 Disease Relevance 0.29 Pain Relevance 0.11

General Comments

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