INT2196

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Context Info
Confidence 0.50
First Reported 1979
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.19
Pain Relevance 2.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (TFF2)
Anatomy Link Frequency
neurons 1
TFF2 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 17 100.00 Very High Very High Very High
Morphine 8 99.98 Very High Very High Very High
Enkephalin 7 99.16 Very High Very High Very High
aspirin 76 98.68 Very High Very High Very High
antagonist 4 94.28 High High
opioid receptor 7 91.36 High High
vagus nerve 3 83.04 Quite High
agonist 1 82.04 Quite High
chemokine 1 62.80 Quite High
cytokine 1 62.20 Quite High
Disease Link Frequency Relevance Heat
Injury 1 80.32 Quite High
INFLAMMATION 3 61.80 Quite High
Aging 3 50.24 Quite High
Gastritis 1 47.24 Quite Low
Hemorrhage 3 33.84 Quite Low
Ulcers 11 26.96 Quite Low
Disease 5 25.92 Quite Low
Dementia 5 5.00 Very Low Very Low Very Low
Frailty 5 5.00 Very Low Very Low Very Low
Infection 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Since TFF peptides play an important role in gastric mucosal protection, indometacin-induced TFF2 may reduce the degree of gastric mucosal damage induced by indometacin.


Positive_regulation (indometacin-induced) of TFF2
1) Confidence 0.50 Published 2004 Journal Aliment. Pharmacol. Ther. Section Body Doc Link 15298624 Disease Relevance 0 Pain Relevance 0
Recent work by our group has shown that the nocturnal peak of mucosally protective TFF2 is lower and earlier in older people (Johns et al 2005), and manipulating the nocturnal increase of cytoprotective TFF2 or encouraging patients to take aspirin at night when the mucosal protective mechanisms are optimal may improve tolerability.
Positive_regulation (increase) of TFF2 associated with aspirin
2) Confidence 0.33 Published 2006 Journal Clinical Interventions in Aging Section Body Doc Link PMC2682452 Disease Relevance 0.13 Pain Relevance 0.20
Investigation of the mechanism responsible for morphine-induced activation of NF-kappaB promoter in NT2-N neurons demonstrated that morphine activates the SP promoter and induces SP expression in these cells.
Positive_regulation (activates) of SP in neurons associated with substance p and morphine
3) Confidence 0.23 Published 2004 Journal J. Neurosci. Res. Section Abstract Doc Link 14743438 Disease Relevance 0.06 Pain Relevance 1.78
Very high numbers of SP-, medium numbers of ENK-, and low number of VIP-immunoreactive fibers were seen.
Positive_regulation (numbers) of SP associated with enkephalin and substance p
4) Confidence 0.20 Published 1979 Journal Gastroenterology Section Abstract Doc Link 378753 Disease Relevance 0 Pain Relevance 0.86

General Comments

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