INT219610

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Context Info
Confidence 0.90
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 4.47
Pain Relevance 0.54

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (SAA1)
Anatomy Link Frequency
monocyte 2
SAA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 12 89.60 High High
Inflammation 74 79.92 Quite High
cytokine 4 78.88 Quite High
Inflammatory marker 15 34.44 Quite Low
rheumatoid arthritis 15 5.44 Low Low
Pain 18 5.00 Very Low Very Low Very Low
Paracetamol 13 5.00 Very Low Very Low Very Low
Crohn's disease 6 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 57 99.30 Very High Very High Very High
Genetic Predisposition To Disease 3 95.68 Very High Very High Very High
Amyloidosis 135 95.44 Very High Very High Very High
Infection 30 89.68 High High
INFLAMMATION 98 89.20 High High
Periodontal Disease 30 86.76 High High
Foreign Bodies 3 77.64 Quite High
Periodontitis 30 58.96 Quite High
Chronic Periodontitis 15 42.96 Quite Low
Emphysema 3 36.20 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, SAA-protein is normally degraded to soluble end products via monocyte-derived enzymes.
Protein_catabolism (degraded) of SAA-protein in monocyte
1) Confidence 0.90 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.74 Pain Relevance 0.19
Second, a genetically determined structural abnormality in the SAA-protein molecule itself renders it resistant to degradation by monocytes.
Protein_catabolism (degradation) of SAA-protein in monocytes
2) Confidence 0.79 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.31 Pain Relevance 0.18
Conceivably, individuals who develop amyloid have an enzyme defect that cannot breakdown SAA-protein completely hence insoluble AA molecules were produced.
Protein_catabolism (breakdown) of SAA-protein associated with alzheimer's dementia
3) Confidence 0.52 Published 2010 Journal J Med Case Reports Section Body Doc Link PMC2911467 Disease Relevance 1.42 Pain Relevance 0.17
Intake of SAA in a normal population: relationship to the RDA and to the potential loss of sulfate associated with drug metabolism
Protein_catabolism (Intake) of SAA
4) Confidence 0.51 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2198910 Disease Relevance 0 Pain Relevance 0

General Comments

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