INT219648

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.27
First Reported 2008
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 16
Total Number 18
Disease Relevance 8.78
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
body 4
fat 2
other parts 1
Hd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 40 100.00 Very High Very High Very High
Central nervous system 60 99.22 Very High Very High Very High
dexamethasone 140 93.56 High High
corticosteroid 10 86.72 High High
Inflammation 120 85.76 High High
Neuropeptide 10 84.56 Quite High
fibrosis 10 70.00 Quite High
iatrogenic 10 28.08 Quite Low
anesthesia 15 5.00 Very Low Very Low Very Low
sodium channel 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 370 100.00 Very High Very High Very High
Body Weight 95 100.00 Very High Very High Very High
Impaired Glucose Tolerance 40 100.00 Very High Very High Very High
Renal Failure 324 99.64 Very High Very High Very High
Glycosuria 70 98.88 Very High Very High Very High
Hyperlipidemia 280 98.72 Very High Very High Very High
Stress 175 98.36 Very High Very High Very High
Polyuria 30 98.28 Very High Very High Very High
Metabolic Syndrome 270 97.44 Very High Very High Very High
Metabolic Disorder 20 94.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the HD rats, the metabolic complications are significantly less when compared to HF-HD rats, and the duration of the study is also very short to show any minimal changes in the body weight [Table 1]
Gene_expression (rats) of HD in body associated with body weight
1) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.53 Pain Relevance 0
Group IV [HF-HD]: Rats were given 5 ml of high-fat emulsion and Dex at a dose of 250 ?
Gene_expression (emulsion) of HD in fat
2) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0 Pain Relevance 0.03
Then the outcome of the results observed in the HF-HD and HF-LD rats indicates that the effect of persistent stress [8] during positive energy balance [3] might have a pathological role in the development insulin resistance and its related complications.


Gene_expression (rats) of HD associated with stress and insulin resistance
3) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.79 Pain Relevance 0.11
From the results obtained in the HF-HD and HF-LD rats, it can be speculated that the hyperlipidemia might have potentiated the action/availability of normal or mildly elevated cortisol causing metabolic disorders.
Gene_expression (rats) of HD associated with metabolic disorder and hyperlipidemia
4) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 1.52 Pain Relevance 0.07
The exact mechanism of reduction in food intake in the HF-HD and HF-LD is not known, but the hyperlipidemia induced by high-fat feeding might have potentiated the action/availability of Dex in the central nervous system causing reduced food intake in the HF-HD and HF-LD rats.
Gene_expression (rats) of HD in fat associated with central nervous system and hyperlipidemia
5) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.10 Pain Relevance 0.20
On the fourteenth day of the experiment the rats in the HF-HD groups were presented with severe glycosuria and polyuria.
Gene_expression (groups) of HD associated with polyuria and glycosuria
6) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.55 Pain Relevance 0.04
Severe metabolic complications were observed in the HF-HD rats, which might be responsible for the loss of body weight and increased water intake observed in HF-HD rats compared to HD, HF-LD, LD, and HF rats [Table 2].
Gene_expression (rats) of HD in body associated with body weight
7) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.60 Pain Relevance 0
The increased level of Dex in the HD and LD rats might have altered the membrane structure and enter the cell by concentration gradient which in turn have caused insulin resistance and impaired glucose tolerance in the HD and LD rats [Fig. 1 & Table 2] [70,71,73,74].
Gene_expression (resistance) of HD associated with tolerance, insulin resistance and impaired glucose tolerance
8) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 1.00 Pain Relevance 0.05
Severe metabolic complications were observed in the HF-HD rats, which might be responsible for the loss of body weight and increased water intake observed in HF-HD rats compared to HD, HF-LD, LD, and HF rats [Table 2].
Gene_expression (rats) of HD in body associated with body weight
9) Confidence 0.27 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.71 Pain Relevance 0
In some developing and emerging economies, mainly due to inexpensive labour and high imported equipment and solution costs, PD is perceived to be more expensive than HD despite the lack of confirmatory prospective economic evaluations.
Neg (lack) Gene_expression (expensive) of HD associated with renal failure
10) Confidence 0.15 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2441769 Disease Relevance 0.37 Pain Relevance 0
Appropriate alignment of incentives throughout the downstream care system may not occur because cost drivers for PD and HD differ; PD is driven primarily by variable costs while HD is driven more by fixed costs.
Gene_expression (driven) of HD associated with renal failure
11) Confidence 0.15 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2441769 Disease Relevance 0.37 Pain Relevance 0
This change in reimbursement structure arguably contributed to a stabilization of an ongoing reduced utilization of PD and non-hospital-based HD in Ontario, while the utilization of PD continued to decline in other parts of Canada [16].
Gene_expression (based) of HD in other parts associated with renal failure
12) Confidence 0.15 Published 2008 Journal Nephrology Dialysis Transplantation Section Body Doc Link PMC2441769 Disease Relevance 0.76 Pain Relevance 0
Severe metabolic complications were observed in the HF-HD rats, which might be responsible for the loss of body weight and increased water intake observed in HF-HD rats compared to HD, HF-LD, LD, and HF rats [Table 2].
Gene_expression (rats) of HD in body associated with body weight
13) Confidence 0.13 Published 2008 Journal Int Arch Med Section Body Doc Link PMC2414485 Disease Relevance 0.73 Pain Relevance 0
Differentially expressed genes for MSH, PM-HD, and zinc sulfate relative to saline and zinc relative to MSH were identified and grouped manually into functional categories.
Gene_expression (expressed) of PM-HD
14) Confidence 0.09 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199289 Disease Relevance 0.11 Pain Relevance 0
The number of genes affected by zinc was much greater than that changed by MSH or PM-HD suspension (~ 70).
Gene_expression (suspension) of PM-HD
15) Confidence 0.08 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199289 Disease Relevance 0.17 Pain Relevance 0.04
The lesion severity was statistically significant in 8-week rats exposed to MSH or PM-HD suspension (Figure 3).
Gene_expression (suspension) of PM-HD
16) Confidence 0.08 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199289 Disease Relevance 0.22 Pain Relevance 0.11
However, some of the genes that changed in PM-HD were the same as those affected by zinc (Figure 6), suggesting that those genes are changed as a result of exposure to zinc.
Gene_expression (changed) of PM-HD
17) Confidence 0.08 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199289 Disease Relevance 0.11 Pain Relevance 0.03
The following contrasts were made for this study: MSH/saline, PM-HD/saline, Zn/saline, Zn/MSH.
Gene_expression (made) of PM-HD
18) Confidence 0.07 Published 2008 Journal Environ Health Perspect Section Body Doc Link PMC2199289 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox