INT21965

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Context Info
Confidence 0.62
First Reported 1984
Last Reported 2002
Negated 3
Speculated 1
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.26
Pain Relevance 2.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gast) extracellular region (Gast)
Anatomy Link Frequency
plasma 2
neurons 2
Gast (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Somatostatin 18 100.00 Very High Very High Very High
narcan 4 99.84 Very High Very High Very High
tetrodotoxin 5 99.12 Very High Very High Very High
Endogenous opioid 8 98.28 Very High Very High Very High
opiate 1 88.84 High High
anesthesia 1 82.00 Quite High
peptic ulcer disease 1 61.48 Quite High
amygdala 1 46.80 Quite Low
parabrachial 1 45.04 Quite Low
vagus nerve 1 34.80 Quite Low
Disease Link Frequency Relevance Heat
Duodenal Ulcer 2 75.00 Quite High
Disease 1 61.48 Quite High
Ulcers 1 61.16 Quite High
Pernicious Anemia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Naloxone had no effect on the noncholinergic, nonadrenergic stimulation of gastrin levels.
Neg (no) Regulation (effect) of Positive_regulation (stimulation) of gastrin associated with narcan
1) Confidence 0.62 Published 1987 Journal Neuropeptides Section Abstract Doc Link 3614557 Disease Relevance 0 Pain Relevance 0.86
The present study examined whether the central neurons are involved in the stimulatory action of gastrin on the secretion of gastric acid.
Spec (whether) Regulation (involved) of Spec (whether) Positive_regulation (action) of gastrin in neurons
2) Confidence 0.45 Published 2002 Journal Neurosci. Lett. Section Abstract Doc Link 11755239 Disease Relevance 0 Pain Relevance 0.08
The slight increase in plasma gastrin concentration following proximal gastric vagotomy despite a lesser reduction in intragastric acidity may be the result of additional effects on gastrin release by the vagotomy.
Regulation (effects) of Positive_regulation (increase) of gastrin in plasma
3) Confidence 0.44 Published 1990 Journal Gastroenterology Section Abstract Doc Link 2227275 Disease Relevance 0.26 Pain Relevance 0.06
Field stimulation caused an increase in gastrin and somatostatin secretion that was dependent on the strength of the stimulus (10-30 V).
Regulation (dependent) of Positive_regulation (increase) of gastrin associated with somatostatin
4) Confidence 0.27 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.36
DMPP caused lesser, though significant, increases in gastrin (166%) and somatostatin (83%) secretion that were nearly abolished by hexamethonium (84-91%) but were not significantly affected by atropine.
Neg (not) Regulation (affected) of Positive_regulation (increases) of gastrin associated with somatostatin
5) Confidence 0.27 Published 1987 Journal Am. J. Physiol. Section Abstract Doc Link 2892415 Disease Relevance 0 Pain Relevance 0.48
GRP caused a dose-dependent increase in antral gastrin output which was not significantly altered by administration of tetrodotoxin.
Neg (not) Regulation (altered) of Positive_regulation (increase) of gastrin associated with tetrodotoxin
6) Confidence 0.25 Published 1984 Journal Life Sci. Section Abstract Doc Link 6482663 Disease Relevance 0 Pain Relevance 0.27

General Comments

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