INT21967

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Context Info
Confidence 0.31
First Reported 1983
Last Reported 2009
Negated 1
Speculated 1
Reported most in Abstract
Documents 5
Total Number 7
Disease Relevance 5.72
Pain Relevance 6.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Pag1) intracellular (Pag1)
Anatomy Link Frequency
spinal 2
neuronal 2
neurons 2
nucleus 2
PAG 2
Pag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central grey 179 100.00 Very High Very High Very High
Periaqueductal grey 6 100.00 Very High Very High Very High
monoamine 2 100.00 Very High Very High Very High
Opioid 6 99.76 Very High Very High Very High
opiate 4 99.36 Very High Very High Very High
Pain 37 99.28 Very High Very High Very High
Enkephalin 6 99.26 Very High Very High Very High
antinociception 6 99.10 Very High Very High Very High
antagonist 32 97.98 Very High Very High Very High
Serotonin 4 97.94 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 188 100.00 Very High Very High Very High
Pain 44 99.28 Very High Very High Very High
Fever 2 98.56 Very High Very High Very High
Injury 34 97.60 Very High Very High Very High
Inflammatory Pain 26 95.28 Very High Very High Very High
Hyperalgesia 18 95.12 Very High Very High Very High
Nociception 20 90.84 High High
Targeted Disruption 2 88.48 High High
INFLAMMATION 42 81.36 Quite High
Neuropathic Pain 8 58.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Significant increases and decreases in firing rate were detected in both neuronal groups: only 4% of the sound-responding units were insensitive to PAG stimulation while the 'spontaneous' units showed significantly smaller changes in firing rate in response to PAG stimulation.
Positive_regulation (insensitive) of Positive_regulation (stimulation) of PAG in neuronal associated with central grey
1) Confidence 0.31 Published 1990 Journal Hear. Res. Section Abstract Doc Link 2228805 Disease Relevance 0.65 Pain Relevance 0.58
In some experiments show that activation of NMDARs in the PAG causes an inhibition of pain response [21,43,44], while others show that NMDARs may play a critical role in induction of spinal hyperalgesia after prolonged noxious stimulation [1,2,20].
Positive_regulation (causes) of Positive_regulation (activation) of PAG in spinal associated with pain, hyperalgesia and central grey
2) Confidence 0.25 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.25 Pain Relevance 0.67
Our results demonstrate that NR2B receptor is up-regulated in the PAG and involves in the modulation to the prolonged peripheral injury.


Positive_regulation (up) of Positive_regulation (regulated) of PAG associated with injury and central grey
3) Confidence 0.23 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 1.85 Pain Relevance 1.36
It is possible that electrical stimulation of the PAG activates spinally projecting collaterals of the noradrenergic cells in A5, the locus ceruleus, subceruleus and A7/K├Âlliker-Fuse nucleus.
Spec (possible) Positive_regulation (activates) of Spec (possible) Positive_regulation (stimulation) of PAG in nucleus associated with locus ceruleus and central grey
4) Confidence 0.16 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764343 Disease Relevance 0.59 Pain Relevance 0.69
These behavioral experiments coupled with earlier work provide converging evidence to support the hypothesis that antinociception produced by activating neurons in the LH is mediated in part by the subsequent activation of neurons in the PAG by NK1 receptors.
Positive_regulation (mediated) of Positive_regulation (activation) of PAG in neurons associated with antinociception and central grey
5) Confidence 0.13 Published 2009 Journal Neurosci. Lett. Section Abstract Doc Link 19356605 Disease Relevance 0.60 Pain Relevance 1.03
Acetylcholine, dopamine, noradrenaline, adrenaline, serotonin and histamine may play a transient modulatory role; forebrain-induced vocalization, however, does not depend upon the cholinergic or monoaminergic activation of PAG neurons.
Neg (not) Positive_regulation (depend) of Positive_regulation (activation) of PAG in PAG associated with dopamine, periaqueductal grey, noradrenaline, serotonin and monoamine
6) Confidence 0.11 Published 1993 Journal Eur. J. Neurosci. Section Abstract Doc Link 7903190 Disease Relevance 0.18 Pain Relevance 1.19
The ability of naltrexone, an opiate receptor antagonist, to reverse the hyperthermia induced by beta-endorphin and DAGO suggests that the opioid-stimulated increase in body temperature via the PAG is mediated through the mu-opiate receptor.
Positive_regulation (mediated) of Positive_regulation (increase) of PAG in body associated with antagonist, urological neuroanatomy, enkephalin, opiate, fever and opioid
7) Confidence 0.05 Published 1983 Journal Regul. Pept. Section Abstract Doc Link 6320316 Disease Relevance 0.60 Pain Relevance 1.34

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