INT219682

Context Info Confidence 0.75 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.97 Pain Relevance 2.20

endoplasmic reticulum (CYP4F22)

Anatomy Link Frequency muscles 1 CYP4F22 (Homo sapiens)

Pain Link Frequency Relevance Heat Analgesic 10 99.96 Acupuncture 230 99.92 Potency 1 98.80 electroacupuncture 81 93.92 visual analogue scale 4 93.84 Pain 108 93.56 depression 1 92.16 analgesia 10 68.16 Limbic system 1 58.44 imagery 11 50.00

Disease Link Frequency Relevance Heat Pain 112 93.76 Depression 1 92.16 Urological Neuroanatomy 42 50.00 Hypesthesia 16 41.36 Increased Venous Pressure Under Development 10 5.00 Dyspepsia 9 5.00 Low Back Pain 3 5.00 Nociception 2 5.00 Spasticity 2 5.00 Neuropathic Pain 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Both LI 3 and LI 4 can produce analgesic effects according to acupuncture literature [62,63].

Gene_expression (produce) of LI 3 associated with analgesic and acupuncture

1) Confidence 0.75 Published 2010 Journal Mol Pain Section Body Doc Link PMC2993660 Disease Relevance 0.32 Pain Relevance 0.76

Consistent with the well-known potency of LI4 in analgesic and modulatory actions, acupuncture at LI4 produced the most prominent response in terms of the overall deqi experience, the number of sensations elicited and their intensities, as well as the prevalence of dull pain, an important characteristic of deqi as mentioned earlier.

Gene_expression (produced) of LI4 associated with pain, analgesic, acupuncture and potency

2) Confidence 0.04 Published 2007 Journal BMC Complement Altern Med Section Body Doc Link PMC2200650 Disease Relevance 0.65 Pain Relevance 1.05

Acupuncture stimulation applied to LI4 produced a prominent decrease in maximum FF force, AUC and integrated surface EMG in the flexor muscles during vibratory stimulation.

Gene_expression (produced) of LI4 in muscles associated with acupuncture

3) Confidence 0.01 Published 2010 Journal Acupuncture in Medicine Section Body Doc Link PMC3002759 Disease Relevance 0 Pain Relevance 0.39

General Comments

This test has worked.