INT219695

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Context Info
Confidence 0.40
First Reported 2006
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 24
Total Number 25
Disease Relevance 33.04
Pain Relevance 3.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
lung 6
sputum 4
macrophages 4
heart 2
COPD (Homo sapiens)
Pain Link Frequency Relevance Heat
fibrosis 102 100.00 Very High Very High Very High
cytokine 133 99.74 Very High Very High Very High
metalloproteinase 282 99.58 Very High Very High Very High
cINOD 7 99.16 Very High Very High Very High
Inflammation 564 97.00 Very High Very High Very High
corticosteroid 106 96.96 Very High Very High Very High
agonist 73 96.32 Very High Very High Very High
Catecholamine 1 95.04 Very High Very High Very High
anakinra 2 89.56 High High
Inflammatory response 29 84.32 Quite High
Disease Link Frequency Relevance Heat
Pulmonary Disease 1770 100.00 Very High Very High Very High
Heart Failure 248 100.00 Very High Very High Very High
Chronic Renal Failure 220 100.00 Very High Very High Very High
Chronic Obstructive Pulmonary Disease 156 100.00 Very High Very High Very High
Apnoea 83 100.00 Very High Very High Very High
Idiopathic Pulmonary Fibrosis 69 100.00 Very High Very High Very High
Lung Injury 20 100.00 Very High Very High Very High
Fibrosis 44 99.92 Very High Very High Very High
Hypertension 18 99.36 Very High Very High Very High
INFLAMMATION 572 98.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, as with tiotropium, there is a marked scarcity of information regarding their effectiveness in mild COPD.
Positive_regulation (effectiveness) of Gene_expression (effectiveness) of COPD associated with pulmonary disease
1) Confidence 0.40 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650603 Disease Relevance 0.75 Pain Relevance 0.16
A more liberal use of spirometry in primary care may increase the detection and diagnosis of COPD in the community.


Spec (may) Positive_regulation (increase) of Gene_expression (detection) of COPD associated with pulmonary disease
2) Confidence 0.40 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650603 Disease Relevance 1.53 Pain Relevance 0
The percentage of IS MMP-12+-macrophages was higher in COPD groups compared to healthy subjects groups.
Positive_regulation (higher) of Gene_expression (groups) of COPD in macrophages associated with pulmonary disease and metalloproteinase
3) Confidence 0.38 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 3.13 Pain Relevance 0.30
The amount of BAL MMP-12+-macrophages was also significantly higher in COPD groups than in controls in percentages and absolute values.
Positive_regulation (higher) of Gene_expression (groups) of COPD in macrophages associated with pulmonary disease and metalloproteinase
4) Confidence 0.38 Published 2007 Journal Respir Res Section Body Doc Link PMC2200652 Disease Relevance 2.67 Pain Relevance 0.37
To kill bacteria, neutrophils degranulate, releasing myeloperoxidase, a highly reactive acidic oxidant (Furtmuller et al 2000), which is increased during COPD exacerbations, both in sputum and serum (Aaron et al 2001).
Positive_regulation (increased) of Gene_expression (exacerbations) of COPD in sputum associated with pulmonary disease
5) Confidence 0.36 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629961 Disease Relevance 1.42 Pain Relevance 0.21
Man and colleagues (2004) studied 16 patients with “irreversible” severe COPD after two weeks of treatment with 50?
Positive_regulation (severe) of Gene_expression (severe) of COPD associated with chronic obstructive pulmonary disease
6) Confidence 0.36 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707802 Disease Relevance 0.25 Pain Relevance 0.04
2.2 Whether and to what extent do self-perceived symptoms and care needs of patients with severe to very severe COPD, CHF or CRF affect caregiver burden?
Positive_regulation (severe) of Gene_expression (severe) of COPD associated with chronic renal failure, pulmonary disease and heart failure
7) Confidence 0.33 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.94 Pain Relevance 0
2.1 How are the self-perceived symptoms of patients with severe to very severe COPD, CHF or CRF perceived by their closest relatives?
Positive_regulation (perceived) of Gene_expression (severe) of COPD associated with chronic renal failure, pulmonary disease and heart failure
8) Confidence 0.33 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.93 Pain Relevance 0
3.2 Whether and to what extent do the preferences with regard to life-sustaining treatments of patients with severe to very severe COPD differ from those of patients with end-stage CHF or CRF?
Positive_regulation (severe) of Gene_expression (severe) of COPD associated with chronic renal failure, pulmonary disease and heart failure
9) Confidence 0.33 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.94 Pain Relevance 0
2.1 How are the self-perceived symptoms of patients with severe to very severe COPD, CHF or CRF perceived by their closest relatives?
Positive_regulation (severe) of Gene_expression (severe) of COPD associated with chronic renal failure, pulmonary disease and heart failure
10) Confidence 0.33 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2391145 Disease Relevance 1.91 Pain Relevance 0
The currently available treatments for COPD therapy include:
Positive_regulation (treatments) of Gene_expression (therapy) of COPD associated with pulmonary disease
11) Confidence 0.30 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695191 Disease Relevance 0.96 Pain Relevance 0.07
Improvement in COPD exacerbations
Positive_regulation (Improvement) of Gene_expression (exacerbations) of COPD associated with chronic obstructive pulmonary disease
12) Confidence 0.29 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629967 Disease Relevance 0.35 Pain Relevance 0.04
Higher concentrations of fucomucins are found in the sputum of patients with COPD (Lamblin et al 1977).
Positive_regulation (concentrations) of Gene_expression (found) of COPD in sputum associated with pulmonary disease
13) Confidence 0.27 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2650606 Disease Relevance 0.43 Pain Relevance 0.07
Exacerbations of COPD
Positive_regulation (Exacerbations) of Gene_expression (Exacerbations) of COPD associated with pulmonary disease
14) Confidence 0.23 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2706613 Disease Relevance 0.77 Pain Relevance 0
It is possible that troponin elevations associated with acute exacerbations of COPD arise from right heart strain associated with pulmonary hypertension.11 Additionally, even troponin elevations during COPD exacerbations do not necessarily connote classic acute coronary syndrome (ACS), since stress-related and/or therapeutically administered catecholamines may promote Tako-Tsubo phenomenon.12
Positive_regulation (elevations) of Gene_expression (exacerbations) of COPD in heart associated with stress, acute coronary syndrome, pulmonary disease, catecholamine, hypertension and sprains and strains
15) Confidence 0.21 Published 2010 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2981154 Disease Relevance 1.91 Pain Relevance 0.29
positive areas (Epi+Int and Epi) between the control, COPD and IPF groups differed significantly (Kruskal Wallis test; p = 0.007) while the Hb?
Positive_regulation (while) of Gene_expression (groups) of COPD associated with fibrosis and pulmonary disease
16) Confidence 0.21 Published 2010 Journal Respir Res Section Body Doc Link PMC2949726 Disease Relevance 0.81 Pain Relevance 0.24
with COPD were under treatment with inhaled ?
Positive_regulation (were) of Gene_expression (were) of COPD associated with pulmonary disease
17) Confidence 0.11 Published 2007 Journal Clinical and Developmental Immunology Section Body Doc Link PMC2246041 Disease Relevance 0.96 Pain Relevance 0.11
Effects of CPAP on lung function in coexistent OSA and COPD
Positive_regulation (coexistent) of Gene_expression (function) of COPD in lung associated with apnoea and pulmonary disease
18) Confidence 0.11 Published 2008 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2629968 Disease Relevance 2.00 Pain Relevance 0
However, despite the apparently disappointing results of these early clinical studies, the various approaches aimed at inhibiting IL-1 functions and/or synthesis might be potentially beneficial in COPD, also because of the consequent reduction of TNF-?
Positive_regulation (potentially) of Gene_expression (beneficial) of COPD associated with pulmonary disease
19) Confidence 0.06 Published 2006 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2707155 Disease Relevance 0.81 Pain Relevance 0.27
Therapies for COPD are mainly based on anti-inflammatory drugs for treating asthma, including corticosteroids or theophylline with or without bronchodilators like ?
Positive_regulation (Therapies) of Gene_expression (Therapies) of COPD associated with asthma, corticosteroid, inflammation, pulmonary disease and cinod
20) Confidence 0.05 Published 2007 Journal International Journal of Chronic Obstructive Pulmonary Disease Section Body Doc Link PMC2695202 Disease Relevance 1.48 Pain Relevance 0.49

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