INT2197

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Context Info
Confidence 0.78
First Reported 1970
Last Reported 2011
Negated 9
Speculated 6
Reported most in Abstract
Documents 184
Total Number 190
Disease Relevance 40.04
Pain Relevance 50.57

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Gnrh1) extracellular region (Gnrh1) molecular_function (Gnrh1)
Anatomy Link Frequency
neurons 30
plasma 9
follicle 8
pituitary 7
hypothalamus 6
Gnrh1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 594 100.00 Very High Very High Very High
agonist 354 100.00 Very High Very High Very High
narcan 188 100.00 Very High Very High Very High
Dopamine 184 100.00 Very High Very High Very High
Somatostatin 121 100.00 Very High Very High Very High
Opioid 86 100.00 Very High Very High Very High
opiate 56 100.00 Very High Very High Very High
depression 37 100.00 Very High Very High Very High
monoamine 28 100.00 Very High Very High Very High
Delta opioid receptors 18 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Depression 37 100.00 Very High Very High Very High
Urological Neuroanatomy 668 99.96 Very High Very High Very High
Neuroblastoma 2 99.76 Very High Very High Very High
Reprotox - General 1 41 99.72 Very High Very High Very High
Stress 687 99.66 Very High Very High Very High
Alzheimer's Dementia 364 99.36 Very High Very High Very High
Polycystic Ovary Syndrome 1934 99.18 Very High Very High Very High
Precocious Puberty 564 99.16 Very High Very High Very High
Endometriosis (extended) 41 99.08 Very High Very High Very High
Cancer 302 99.02 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dual label in situ hybridization studies provide evidence that luteinizing hormone-releasing hormone neurons do not synthesize messenger ribonucleic acid for mu, kappa, or delta opiate receptors.
Neg (not) Gene_expression (synthesize) of luteinizing hormone-releasing hormone in neurons associated with opiate
1) Confidence 0.78 Published 1997 Journal Endocrinology Section Title Doc Link 9075729 Disease Relevance 0 Pain Relevance 0.33
Most importantly, however, we showed that the GPT-LHRH produced equivalent, parallel shifts to the right in the dose-response curves for LHRH and naloxone, indicative of competitive inhibition.
Gene_expression (produced) of GPT-LHRH associated with narcan
2) Confidence 0.78 Published 1985 Journal Life Sci. Section Abstract Doc Link 3894852 Disease Relevance 0 Pain Relevance 0.77
There is a concomitant increase in excitatory inputs, mainly noradrenaline, excitatory amino acids, and NPY, which increase the synthesis and release of GnRH at the beginning of the juvenile period and participate in the coupling of GnRH neural activity to the ongoing rhythmic activity of a hypothalamic circadian oscillator. 4.
Gene_expression (synthesis) of GnRH in juvenile associated with noradrenaline and excitatory amino acid
3) Confidence 0.78 Published 1995 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 7648607 Disease Relevance 0 Pain Relevance 0.19
The present studies were undertaken to examine the mechanism by which 4-APP inhibits GnRH synthesis and/or release.
Gene_expression (synthesis) of GnRH
4) Confidence 0.78 Published 1985 Journal Endocrinology Section Abstract Doc Link 3886368 Disease Relevance 0.07 Pain Relevance 0.26
In all 3 groups, the 2nd and 3rd injections of LHRH produced much greater increases in serum concentrations of LH than the 1st injection.
Gene_expression (produced) of LHRH
5) Confidence 0.77 Published 1976 Journal Endocrinology Section Abstract Doc Link 770158 Disease Relevance 0 Pain Relevance 0.10
We reasoned that if dietary restriction reduces GnRH secretion, this would be reflected by a decrease in GnRH synthesis and likewise cellular GnRH mRNA levels.
Gene_expression (synthesis) of GnRH
6) Confidence 0.77 Published 1992 Journal Neuroendocrinology Section Abstract Doc Link 1369602 Disease Relevance 0.31 Pain Relevance 0
Neural control of the synthesis and release of luteinizing hormone-releasing hormone.
Gene_expression (synthesis) of luteinizing hormone in Neural
7) Confidence 0.77 Published 1992 Journal Ciba Found. Symp. Section Title Doc Link 1425026 Disease Relevance 0.06 Pain Relevance 0.88
From this point of view, we selected these regions to observe the change of GnRH expression.
Gene_expression (expression) of GnRH
8) Confidence 0.77 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.32 Pain Relevance 0.04
Morishito et al has reported the animal model that neonatal treatment with Danazol may induce the true precocious puberty in female rats [3], but the hypothalamic GnRH expression was not examined.
Spec (examined) Gene_expression (expression) of GnRH associated with precocious puberty
9) Confidence 0.77 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.33 Pain Relevance 0.04
Effects of herb mixture on GnRH expression by immunohistochemistry
Gene_expression (expression) of GnRH
10) Confidence 0.77 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.09 Pain Relevance 0
Mammalian sexual maturation and adult reproductive function are centrally controlled by a subset of neuroendocrine neurons that produce GnRH.
Gene_expression (produce) of GnRH in neurons
11) Confidence 0.77 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1236957 Disease Relevance 0.06 Pain Relevance 0.03
The plasma levels of follicle-stimulating hormone, luteinizing hormone, corticosterone, testosterone, and estradiol were measured by enzyme immunoassay.
Gene_expression (levels) of luteinizing hormone in follicle
12) Confidence 0.77 Published 2008 Journal Arkh. Patol. Section Abstract Doc Link 19227281 Disease Relevance 0 Pain Relevance 0.43
Pubertal changes in gonadotropin-releasing hormone and proopiomelanocortin gene expression in the brain of the male rat.
Gene_expression (expression) of gonadotropin-releasing hormone in brain
13) Confidence 0.77 Published 1989 Journal Endocrinology Section Title Doc Link 2647464 Disease Relevance 0.06 Pain Relevance 0
We conclude that the GnRH gene is fully expressed well before the time of normal puberty onset and that the increase in POMC mRNA that occurs with the onset of puberty may be important for the development of pulsatile GnRH secretion.
Gene_expression (expressed) of GnRH
14) Confidence 0.77 Published 1989 Journal Endocrinology Section Abstract Doc Link 2647464 Disease Relevance 0.06 Pain Relevance 0.20
Additionally, although the magnitude of the increase in Fos-expressing GnRH neurons did not change in old males compared to young males, it was attenuated by almost half in old females compared to young females.
Gene_expression (expressing) of GnRH in neurons
15) Confidence 0.77 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20097261 Disease Relevance 0 Pain Relevance 0.23
We revealed by immunocytochemistry that, regardless of age and sex, naloxone significantly increased the number of GnRH neurons expressing Fos, which was associated with increased LH secretion.
Gene_expression (expressing) of GnRH in neurons associated with narcan
16) Confidence 0.77 Published 2010 Journal Neurosci. Lett. Section Abstract Doc Link 20097261 Disease Relevance 0 Pain Relevance 0.22
Luteinizing hormone-releasing hormone (LHRH) biosynthesis and secretion in embryonic LHRH.
Gene_expression (biosynthesis) of Luteinizing hormone-releasing hormone
17) Confidence 0.77 Published 2000 Journal Endocrinology Section Title Doc Link 11108259 Disease Relevance 0 Pain Relevance 0.15
In this study, we evaluated LHRH biosynthesis and secretion in embryonic LHRH neurons maintained in nasal explants.
Gene_expression (biosynthesis) of LHRH in nasal
18) Confidence 0.77 Published 2000 Journal Endocrinology Section Abstract Doc Link 11108259 Disease Relevance 0 Pain Relevance 0.10
Luteinizing hormone-releasing hormone (LHRH) biosynthesis and secretion in embryonic LHRH.
Gene_expression (biosynthesis) of LHRH
19) Confidence 0.77 Published 2000 Journal Endocrinology Section Title Doc Link 11108259 Disease Relevance 0 Pain Relevance 0.15
Luteinizing hormone-releasing hormone (LHRH) biosynthesis and secretion in embryonic LHRH.
Gene_expression (biosynthesis) of LHRH
20) Confidence 0.77 Published 2000 Journal Endocrinology Section Title Doc Link 11108259 Disease Relevance 0 Pain Relevance 0.15

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