INT219713

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Context Info
Confidence 0.29
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.63
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoskeleton (Spna1) molecular_function (Spna1) cytoplasm (Spna1)
Anatomy Link Frequency
brain 2
hippocampus 2
Spna1 (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 32 98.28 Very High Very High Very High
nMDA receptor 2 91.84 High High
agonist 4 91.00 High High
antagonist 2 86.76 High High
Pain 12 71.32 Quite High
long-term potentiation 4 20.32 Low Low
cytokine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
amygdala 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Toxicity 6 99.98 Very High Very High Very High
Disease 173 99.54 Very High Very High Very High
Neurodegenerative Disease 24 99.08 Very High Very High Very High
Cognitive Disorder 78 96.48 Very High Very High Very High
Cytomegalovirus Infection 1 90.52 High High
Pain 12 71.32 Quite High
Sprains And Strains 28 66.16 Quite High
Immunization 29 61.52 Quite High
Targeted Disruption 26 54.60 Quite High
Influenza Virus Infection 97 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, (i) HA accelerates pathological changes in AD; and (ii) HA toxicity decreases with anti-HA antibody, which induces strong neurogenesis in the hippocampus, resulting in marked recovery of memory performance.
Negative_regulation (decreases) of Gene_expression (antibody) of anti-HA in hippocampus associated with cognitive disorder, toxicity, hippocampus, neurodegenerative disease and disease
1) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.24 Pain Relevance 0.47
(HA vaccine administered to 12-month-old 3xTg-AD mice, and three months later the urinary HA level was measured; Table 3) Also HA vaccine specifically decreased HA level in mice brain at 12 months old (Table 3b).


Negative_regulation (decreased) of Gene_expression (level) of HA in brain associated with disease
2) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2808336 Disease Relevance 1.17 Pain Relevance 0.05
Surprisingly, there was little change in the dissociation rate of VLP elicited antibodies when tested against the heterologous Viet Nam clade 1 HA antigen (3.01×10?
Negative_regulation (clade 1) of Gene_expression (antigen) of HA
3) Confidence 0.09 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2200794 Disease Relevance 0.07 Pain Relevance 0
Three separate replication-defective rAd serotype 5 vectors expressing HA (KAN-1), NP (KAN-1), and M2 (KAN-1) genes were produced as previously described [23].
Negative_regulation (defective) of Gene_expression (expressing) of HA
4) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2843722 Disease Relevance 0.15 Pain Relevance 0

General Comments

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