INT219759

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Context Info
Confidence 0.68
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.53
Pain Relevance 0.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hcls1) plasma membrane (Hcls1) nucleus (Hcls1)
cytoplasm (Hcls1)
Anatomy Link Frequency
plasma 1
platelets 1
Hcls1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 18 98.44 Very High Very High Very High
Analgesic 3 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 3 95.52 Very High Very High Very High
Injury 3 86.96 High High
Hemorrhage 15 84.08 Quite High
Coagulation Disorder 3 75.96 Quite High
Thrombosis 15 72.56 Quite High
Targeted Disruption 6 34.56 Quite Low
Cicatrix 18 6.12 Low Low
Adhesions 6 5.00 Very Low Very Low Very Low
Stress 3 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Again, no difference was observed in ATP secretion between WT and HS1-/- platelets in response to the three agonists (Figure 4G, H &4I).
Localization (secretion) of HS1 in platelets associated with agonist
1) Confidence 0.68 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.07 Pain Relevance 0.18
It is feasible that these relatively small differences could be due to HS1's role in actin dynamics, although the authors do not discuss their results in relation to the actin cytoskeleton and indeed do not propose a mechanism for this defect.
Localization (role) of HS1
2) Confidence 0.63 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.36 Pain Relevance 0.05
Subsequent to phosphorylation in platelets, HS1 translocates to the plasma membrane [14] where it is postulated to be involved in the morphological changes observed during apoptosis [14,15].
Localization (translocates) of HS1 in plasma associated with apoptosis
3) Confidence 0.63 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.10 Pain Relevance 0

General Comments

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