INT219759

Context Info Confidence 0.68 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 3 Disease Relevance 0.53 Pain Relevance 0.22

mitochondrion (Hcls1) plasma membrane (Hcls1) nucleus (Hcls1) cytoplasm (Hcls1)

Anatomy Link Frequency plasma 1 platelets 1 Hcls1 (Mus musculus)

Pain Link Frequency Relevance Heat agonist 18 98.44 Analgesic 3 5.00 Buprenorphine 3 5.00

Disease Link Frequency Relevance Heat Apoptosis 3 95.52 Injury 3 86.96 Hemorrhage 15 84.08 Coagulation Disorder 3 75.96 Thrombosis 15 72.56 Targeted Disruption 6 34.56 Cicatrix 18 6.12 Adhesions 6 5.00 Stress 3 5.00 Disseminated Intravascular Coagulation 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Again, no difference was observed in ATP secretion between WT and HS1-/- platelets in response to the three agonists (Figure 4G, H &4I).

Localization (secretion) of HS1 in platelets associated with agonist

1) Confidence 0.68 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.07 Pain Relevance 0.18

It is feasible that these relatively small differences could be due to HS1's role in actin dynamics, although the authors do not discuss their results in relation to the actin cytoskeleton and indeed do not propose a mechanism for this defect.

Localization (role) of HS1

2) Confidence 0.63 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.36 Pain Relevance 0.05

Subsequent to phosphorylation in platelets, HS1 translocates to the plasma membrane [14] where it is postulated to be involved in the morphological changes observed during apoptosis [14,15].

Localization (translocates) of HS1 in plasma associated with apoptosis

3) Confidence 0.63 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.10 Pain Relevance 0

General Comments

This test has worked.