INT219763

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Context Info
Confidence 0.35
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0.92
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hcls1) plasma membrane (Hcls1) nucleus (Hcls1)
cytoplasm (Hcls1)
Anatomy Link Frequency
platelets 2
T-cells 1
Hcls1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 24 95.88 Very High Very High Very High
Analgesic 4 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 4 97.08 Very High Very High Very High
Thrombosis 20 93.92 High High
Adhesions 8 76.96 Quite High
Targeted Disruption 8 63.28 Quite High
Hemorrhage 20 61.12 Quite High
Cicatrix 24 5.00 Very Low Very Low Very Low
Coagulation Disorder 4 5.00 Very Low Very Low Very Low
Injury 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies on the actin-binding protein HS1 in platelets

Background

HS1 Binding (binding) of in platelets
1) Confidence 0.35 Published 2007 Journal BMC Cell Biol Section Title Doc Link PMC2203996 Disease Relevance 0.35 Pain Relevance 0
The Arp2/3 complex is highly regulated by a number of actin-binding proteins including the haematopoietic-specific protein HS1 and its homologue cortactin.
HS1 Binding (binding) of
2) Confidence 0.35 Published 2007 Journal BMC Cell Biol Section Abstract Doc Link PMC2203996 Disease Relevance 0.34 Pain Relevance 0
This data, in conjunction with the spreading data presented above, indicates that abrogation of HS1 does not impair the ability of platelets to respond to stimuli and to successfully transduce the signals required for shape change, aggregation and secretion.


HS1 Binding (abrogation) of in platelets
3) Confidence 0.31 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.09 Pain Relevance 0.17
In B- and T-cells, tyrosine phosphorylation is involved in the migration of HS1 to lipid rafts where it is proposed to mediate actin assembly [16].
HS1 Binding (migration) of in T-cells
4) Confidence 0.31 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.15 Pain Relevance 0

General Comments

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