INT219776

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 1.85
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Hcls1) plasma membrane (Hcls1) nucleus (Hcls1)
cytoplasm (Hcls1)
Anatomy Link Frequency
platelets 3
blood 1
Hcls1 (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 30 63.44 Quite High
Analgesic 5 5.00 Very Low Very Low Very Low
Buprenorphine 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cicatrix 30 100.00 Very High Very High Very High
Coagulation Disorder 5 99.12 Very High Very High Very High
Thrombosis 25 93.48 High High
Hemorrhage 25 83.64 Quite High
Adhesions 10 76.96 Quite High
Injury 5 75.36 Quite High
Stress 5 67.52 Quite High
Targeted Disruption 10 59.76 Quite High
Apoptosis 5 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is feasible that other activators of the Arp2/3 complex are able to compensate for the loss of HS1 in platelets.
Negative_regulation (loss) of HS1 in platelets
1) Confidence 0.49 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.46 Pain Relevance 0
We did observe a small reduction in the level of Scar/WAVE1 in HS1-/- platelets compared to WT.
Negative_regulation (reduction) of HS1 in platelets associated with cicatrix
2) Confidence 0.42 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.57 Pain Relevance 0
The Arp2/3 complex is highly regulated by a number of actin-binding proteins including the haematopoietic-specific protein HS1 and its homologue cortactin.
Negative_regulation (number) of HS1
3) Confidence 0.42 Published 2007 Journal BMC Cell Biol Section Abstract Doc Link PMC2203996 Disease Relevance 0.34 Pain Relevance 0
No significant difference was observed between the two genotypes in the volume of blood lost in 10 min (P = 0.852, ns) demonstrating that absence of HS1 does not result in a bleeding disorder.
Negative_regulation (absence) of HS1 in blood associated with coagulation disorder
4) Confidence 0.36 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.48 Pain Relevance 0.03
It is therefore important to extend this work to platelets deficient in cortactin and in both cortactin and HS1.


Negative_regulation (deficient) of HS1 in platelets
5) Confidence 0.18 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0 Pain Relevance 0

General Comments

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