INT219780

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Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 23
Total Number 23
Disease Relevance 2.27
Pain Relevance 0.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mRNA processing (AICDA) cytoplasm (AICDA)
Anatomy Link Frequency
lateral 1
arm 1
brain 1
platelets 1
AICDA (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 20 82.36 Quite High
Multiple sclerosis 12 75.64 Quite High
Central nervous system 1 70.44 Quite High
backache 1 50.12 Quite High
chemokine 1 48.20 Quite Low
cytokine 1 47.60 Quite Low
Inflammation 1 46.32 Quite Low
cerebral cortex 20 45.92 Quite Low
rheumatoid arthritis 7 40.48 Quite Low
spinal inflammation 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Autoimmune Disease 45 100.00 Very High Very High Very High
Shock 20 99.24 Very High Very High Very High
Convulsion 40 96.92 Very High Very High Very High
Cicatrix 6 88.64 High High
Unconsciousness 20 86.36 High High
Epilepsy 20 84.40 Quite High
Disease 23 84.08 Quite High
Systemic Lupus Erythematosus 6 83.80 Quite High
Coma 40 83.28 Quite High
Diabetes Mellitus 17 76.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It is feasible that other activators of the Arp2/3 complex are able to compensate for the loss of HS1 in platelets.
Positive_regulation (activators) of Arp2 in platelets
1) Confidence 0.49 Published 2007 Journal BMC Cell Biol Section Body Doc Link PMC2203996 Disease Relevance 0.39 Pain Relevance 0
Viral/bacterial antigens may trigger AID through molecular mimicry and via acting as superantigens.
Positive_regulation (trigger) of AID associated with autoimmune disease
2) Confidence 0.10 Published 2007 Journal Current Genomics Section Body Doc Link PMC2647156 Disease Relevance 1.19 Pain Relevance 0.11
The arm position in the LA view was the clavicular arm position with elbows flexed at 45° and fists resting on the ipsilateral clavicles as described by Faro et al.9 (Fig. 2b).Figure 2Arm positions in AP (a) and LA (b) view while standing on the BalancAid
Positive_regulation (standing) of BalancAid in arm
3) Confidence 0.09 Published 2010 Journal Ann Biomed Eng Section Body Doc Link PMC2940050 Disease Relevance 0.10 Pain Relevance 0.05
Adding feedback and lateral connections to a feedforward network can potentially increase the integrated information generated by a system by increasing the number of non-redundant causal interactions.


Positive_regulation (increase) of integrated in lateral
4) Confidence 0.04 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Note that the systems in the figure generate (minimal amounts of) integrated information even when they remain inactive for long periods.
Positive_regulation (generate) of integrated
5) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
No integrated information is generated by the replay, and (potentially) high integrated information is generated by the causally interacting system.

?

Positive_regulation (generated) of integrated
6) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
No integrated information is generated by the replay, and (potentially) high integrated information is generated by the causally interacting system.

?

Positive_regulation (generated) of integrated
7) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
No integrated information is generated by the replay, and (potentially) high integrated information is generated by the causally interacting system.

?

Positive_regulation (high) of integrated
8) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
However, the sensory sheet does not determine the integrated information generated by the system; instead we need to find the minimum information partition.
Neg (not) Positive_regulation (generated) of integrated
9) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
In contrast, perturbing the systems and measuring integrated information does discriminate between the two situations.
Positive_regulation (measuring) of integrated
10) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Strict feedforward architectures are inefficient for generating integrated information
Positive_regulation (generating) of integrated
11) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Finding the integrated information generated by a physical system requires analyzing it from the ground up, without preconception regarding the nature of its elementary units.
Positive_regulation (generated) of integrated
12) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Thus, depending on the architecture of the system in question, integrated information may potentially be generated even when the system is in a fixed state and appears to be doing nothing.
Positive_regulation (generated) of integrated
13) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0.05 Pain Relevance 0.06
We also saw that a simplified model of bistable dynamics, loosely resembling slow-wave sleep early in the night, when consciousness fades, is not able to sustain high values of integrated information.
Positive_regulation (values) of integrated
14) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0.25 Pain Relevance 0
Why do attractors and their neighbors generate low integrated information?
Positive_regulation (low) of integrated
15) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
In contrast, when hyperactive the systems in Figure 9A and 9C generate no integrated information.
Neg (no) Positive_regulation (generate) of integrated
16) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
The notion of integrated information is motivated by the need for a measure that captures the two basic phenomenological properties of consciousness: i) each conscious experience generates a huge amount of information by virtue of being one of a vast repertoire of alternatives; and ii) each conscious state is integrated, meaning that it is experienced as a whole and does not decompose into independent parts.
Positive_regulation (motivated) of integrated
17) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Everything else being equal, it appears that high values of integrated information can be obtained by architectures that conjoin functional specialization with functional integration.
Positive_regulation (values) of integrated
18) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
The impossibility of measuring integrated information for larger systems is due to the combinatorial explosion in the partitions of a system as the number of elements is increased.
Positive_regulation (measuring) of integrated
19) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0
Figure 7 shows two examples of systems that appear to generate a large amount of integrated information, but on closer analysis dissolve into many weakly interacting components with low ?.
Positive_regulation (generate) of integrated
20) Confidence 0.03 Published 2008 Journal PLoS Computational Biology Section Body Doc Link PMC2386970 Disease Relevance 0 Pain Relevance 0

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