INT219848

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.63
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 5.32
Pain Relevance 0.43

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Oas1b (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 51 98.62 Very High Very High Very High
Inflammatory response 15 87.20 High High
depression 10 81.72 Quite High
nud 24 64.56 Quite High
chemokine 15 53.36 Quite High
abdominal pain 4 26.80 Quite Low
Central nervous system 33 8.00 Low Low
sSRI 26 5.00 Very Low Very Low Very Low
antidepressant 18 5.00 Very Low Very Low Very Low
cytokine 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Togavirus Infection 225 99.20 Very High Very High Very High
Infection 159 99.12 Very High Very High Very High
Apoptosis 48 98.84 Very High Very High Very High
INFLAMMATION 66 98.62 Very High Very High Very High
Adverse Drug Reaction 14 97.98 Very High Very High Very High
Urological Neuroanatomy 6 95.76 Very High Very High Very High
Vomiting 52 92.68 High High
Disease 31 91.76 High High
Targeted Disruption 6 85.68 High High
Depression 22 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These include Ifi27, Ifih1, Irf7 and Oas1b which were upregulated at 72 hr and 96 hr post infection except Becn1 that was over-expressed only at 72 hr post infection, and Spn which was over-expressed at all time points.


Positive_regulation (upregulated) of Oas1b associated with urological neuroanatomy and infection
1) Confidence 0.63 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.40 Pain Relevance 0.21
Our results demonstrate that genes related to important immune pathways such as antigen presentation, inflammation, apoptosis and response to virus (Cxcl10, CxCl11, Ccl5, Ifr7, Ifi27 Oas1b, Fcerg1,Mif, Clusterin and MHC class II) were upregulated as a result of virus infection.
Positive_regulation (upregulated) of Oas1b associated with inflammation, apoptosis and infection
2) Confidence 0.42 Published 2008 Journal BMC Genomics Section Abstract Doc Link PMC2440554 Disease Relevance 1.15 Pain Relevance 0.09
Since VEEV is a positive single strand RNA virus, increased Oas1b levels may also potentially inhibit VEEV replication.
Positive_regulation (increased) of Oas1b associated with togavirus infection
3) Confidence 0.42 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2440554 Disease Relevance 1.30 Pain Relevance 0
In both groups, most adverse events appeared just after beginning treatment or within several days after increasing the dose of FLV.
Positive_regulation (increasing) of FLV
4) Confidence 0.30 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2204024 Disease Relevance 0.85 Pain Relevance 0.07
Because of adverse reactions, 12 subjects in the FLV group and 6 subjects in the FLV+TJ-43 group asked for medication or stopped taking FLV during the investigation period.
Positive_regulation (taking) of FLV associated with adverse drug reaction
5) Confidence 0.21 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2204024 Disease Relevance 0.63 Pain Relevance 0.06

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox