INT2199

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Context Info
Confidence 0.67
First Reported 1979
Last Reported 1993
Negated 1
Speculated 0
Reported most in Abstract
Documents 18
Total Number 19
Disease Relevance 0.18
Pain Relevance 15.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neural 6
hypothalamus 4
median eminence 2
Rhd (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 42 99.96 Very High Very High Very High
narcan 42 99.92 Very High Very High Very High
Clonidine 9 99.92 Very High Very High Very High
addiction 6 99.90 Very High Very High Very High
noradrenaline 63 99.84 Very High Very High Very High
Enkephalin 8 99.80 Very High Very High Very High
Morphine 54 99.64 Very High Very High Very High
antagonist 69 99.30 Very High Very High Very High
opiate 14 99.28 Very High Very High Very High
Opioid 28 99.02 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aging 2 94.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Addition of the opioid antagonist naloxone in vitro resulted in a 220% increase in the release of LH-RH by hypothalami exposed to morphine for 48 h in vivo, whereas it caused a 50% reduction in LH-RH release from tissues exposed to morphine for 96 h in vivo.
Positive_regulation (increase) of Localization (release) of LH-RH associated with antagonist, narcan, opioid and morphine
1) Confidence 0.67 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.47
Maintenance of tissues exposed to morphine in vivo in medium containing morphine in vitro did not alter the increased basal release of LH-RH, but because this was significantly greater than control rates, tolerance is not believed to have occurred.
Neg (not) Positive_regulation (increased) of Localization (release) of LH-RH associated with tolerance and morphine
2) Confidence 0.67 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.23
Naloxone stimulated a greater than 50% increase in LH-RH release from most fragments that contained primarily LH-RH axons and terminals and from all tissue fragments that contained the majority of LH-RH cell bodies as well as axons and terminals.
Positive_regulation (increase) of Localization (release) of LH-RH associated with narcan
3) Confidence 0.66 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.09 Pain Relevance 0.54
The effects of some adrenoceptor agonists (10(-5) M) on LH-RH release were tested: only phenylephrine (alpha 1-agonist) stimulated LH-RH release; clonidine (alpha 2 greater than alpha 1-agonist) and isoproterenol (beta-agonist) were ineffective.
Positive_regulation (stimulated) of Localization (release) of LH-RH associated with agonist and clonidine
4) Confidence 0.57 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.77
Adrenoceptor antagonists (10(-6) M) were also tested: prazosin (alpha 1-antagonist) and phentolamine (alpha 1/alpha 2-antagonist) almost completely suppressed the enhanced release of LH-RH induced by NA.
Positive_regulation (induced) of Localization (release) of LH-RH associated with antagonist and noradrenaline
5) Confidence 0.57 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.83
Adrenoceptor antagonists (10(-6) M) were also tested: prazosin (alpha 1-antagonist) and phentolamine (alpha 1/alpha 2-antagonist) almost completely suppressed the enhanced release of LH-RH induced by NA.
Positive_regulation (enhanced) of Localization (release) of LH-RH associated with antagonist and noradrenaline
6) Confidence 0.57 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.83
Among seven PGs tested at 10(-6) M, only PGE2, PGE1, PGA2, and 16,16-dimethyl PGE2 significantly enhanced LH-RH secretion. 8-iso PGE2 weakly stimulated LH-RH secretion, whereas PGF2 alpha and PGD2 were ineffective.
Positive_regulation (stimulated) of Localization (secretion) of LH-RH
7) Confidence 0.57 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.79
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Positive_regulation (occurred) of Localization (release) of LH-RH in neural associated with addiction, opiate and morphine
8) Confidence 0.48 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.09
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Positive_regulation (rates) of Localization (release) of LH-RH in neural associated with addiction, opiate and morphine
9) Confidence 0.48 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 0.93
Within 16-24 h after morphine treatment, basal LH-RH release rates were observed to be higher compared to those from hypothalami derived from opiate-naive rats, suggesting that dependence had occurred in the neural mechanisms underlying LH-RH release.
Positive_regulation (rates) of Localization (release) of LH-RH in neural associated with addiction, opiate and morphine
10) Confidence 0.48 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 0.93
Addition of the opioid antagonist naloxone in vitro resulted in a 220% increase in the release of LH-RH by hypothalami exposed to morphine for 48 h in vivo, whereas it caused a 50% reduction in LH-RH release from tissues exposed to morphine for 96 h in vivo.
Positive_regulation (caused) of Localization (release) of LH-RH associated with antagonist, narcan, opioid and morphine
11) Confidence 0.45 Published 1988 Journal Brain Res. Section Abstract Doc Link 3075144 Disease Relevance 0 Pain Relevance 1.49
The present study utilizes an in vitro perifusion paradigm to compare the ability of opiate receptor blockade with naloxone to stimulate LH-RH release from tissue fragments from ovariectomized, estrogen-treated young and middle-aged females.
Positive_regulation (stimulate) of Localization (release) of LH-RH associated with narcan and opiate
12) Confidence 0.45 Published 1993 Journal Brain Res. Section Abstract Doc Link 8431770 Disease Relevance 0.09 Pain Relevance 0.44
Among seven PGs tested at 10(-6) M, only PGE2, PGE1, PGA2, and 16,16-dimethyl PGE2 significantly enhanced LH-RH secretion. 8-iso PGE2 weakly stimulated LH-RH secretion, whereas PGF2 alpha and PGD2 were ineffective.
Positive_regulation (enhanced) of Localization (secretion) of LH-RH
13) Confidence 0.41 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.80
Noradrenaline (NA) and prostaglandin (PG) E2 produced a dose-related stimulation of luteinizing hormone releasing hormone (LH-RH) release from incubated median eminence of adult male rats, with ED50 values of 6.10(-7) and 8.10(-8) M, respectively.
Positive_regulation (stimulation) of Localization (release) of LH-RH in median eminence associated with noradrenaline
14) Confidence 0.41 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.53
Among seven PGs tested at 10(-6) M, only PGE2, PGE1, PGA2, and 16,16-dimethyl PGE2 significantly enhanced LH-RH secretion. 8-iso PGE2 weakly stimulated LH-RH secretion, whereas PGF2 alpha and PGD2 were ineffective.
Positive_regulation (enhanced) of Localization (secretion) of LH-RH
15) Confidence 0.41 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.80
The effects of some adrenoceptor agonists (10(-5) M) on LH-RH release were tested: only phenylephrine (alpha 1-agonist) stimulated LH-RH release; clonidine (alpha 2 greater than alpha 1-agonist) and isoproterenol (beta-agonist) were ineffective.
Positive_regulation (stimulated) of Localization (release) of LH-RH associated with agonist and clonidine
16) Confidence 0.41 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.77
Among seven PGs tested at 10(-6) M, only PGE2, PGE1, PGA2, and 16,16-dimethyl PGE2 significantly enhanced LH-RH secretion. 8-iso PGE2 weakly stimulated LH-RH secretion, whereas PGF2 alpha and PGD2 were ineffective.
Positive_regulation (stimulated) of Localization (secretion) of LH-RH
17) Confidence 0.41 Published 1984 Journal Neuroendocrinology Section Abstract Doc Link 6096749 Disease Relevance 0 Pain Relevance 0.79
However 10(-5)--10(-5) M synthetic enkephalin analogue induced a dose-dependent inhibition of LH-RH content and release of the mediobasal hypothalamus, which was prevented by equimolar concentrations of naloxone.
Positive_regulation (induced) of Localization (release) of LH-RH in hypothalamus associated with narcan and enkephalin
18) Confidence 0.14 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 379712 Disease Relevance 0 Pain Relevance 0.30
However 10(-5)--10(-5) M synthetic enkephalin analogue induced a dose-dependent inhibition of LH-RH content and release of the mediobasal hypothalamus, which was prevented by equimolar concentrations of naloxone.
Positive_regulation (induced) of Localization (release) of LH-RH in hypothalamus associated with narcan and enkephalin
19) Confidence 0.14 Published 1979 Journal Neurosci. Lett. Section Abstract Doc Link 379712 Disease Relevance 0 Pain Relevance 0.30

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