INT21990

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Context Info
Confidence 0.42
First Reported 1990
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 17
Total Number 18
Disease Relevance 8.45
Pain Relevance 4.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctrc)
Anatomy Link Frequency
bile 2
leukocyte 1
fat 1
duodenum 1
appendix 1
Ctrc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 31 100.00 Very High Very High Very High
antagonist 5 100.00 Very High Very High Very High
Catecholamine 1 100.00 Very High Very High Very High
Nicotine 8 99.84 Very High Very High Very High
qutenza 13 99.38 Very High Very High Very High
Opioid 1 98.92 Very High Very High Very High
Calcitonin gene-related peptide 15 98.16 Very High Very High Very High
local anesthetic 1 96.76 Very High Very High Very High
adenocard 1 95.84 Very High Very High Very High
agonist 5 91.76 High High
Disease Link Frequency Relevance Heat
Suicidal Behaviour 6 97.40 Very High Very High Very High
Syndrome 12 96.96 Very High Very High Very High
Pancreatitis 37 96.04 Very High Very High Very High
Ulcers 52 94.88 High High
Pain 4 90.80 High High
Common Cold 2 89.96 High High
Malaria 2 85.04 High High
Cystic Fibrosis 10 82.56 Quite High
Apoptosis 20 82.16 Quite High
INFLAMMATION 6 81.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONCLUSION: Our data suggest that when the appendix can be visualized, CTRC can accurately identify a normal appendix and reduce the number of children hospitalized for observation for possible appendicitis.


Negative_regulation (reduce) of CTRC in appendix
1) Confidence 0.42 Published 2005 Journal Pediatr Radiol Section Body Doc Link 15633057 Disease Relevance 0 Pain Relevance 0
There were no significant differences between cisapride and placebo periods in nutritional status, x-ray scores, pulmonary function, food intake (fat, protein, calories), stool size and consistency, and fecal losses of fat, bile acids, chymotrypsin, and calories.
Negative_regulation (losses) of chymotrypsin in bile associated with bile
2) Confidence 0.37 Published 1990 Journal J. Pediatr. Section Abstract Doc Link 2231217 Disease Relevance 1.65 Pain Relevance 0.29
Residual responses after NO synthase inhibitors or after alpha-chymotrypsin were further reduced by pretreatment with alpha-chymotrypsin or NO synthase inhibitors, respectively.
Negative_regulation (reduced) of alpha-chymotrypsin
3) Confidence 0.31 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7600457 Disease Relevance 0 Pain Relevance 0.09
The pancreatic amylase activity, fecal activity of chymotrypsin, pancreatic nucleic acids content and DNA synthesis were decreased.
Negative_regulation (decreased) of chymotrypsin
4) Confidence 0.25 Published 2000 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11016864 Disease Relevance 0.54 Pain Relevance 0.64
Residual responses after NO synthase inhibitors or after alpha-chymotrypsin were further reduced by pretreatment with alpha-chymotrypsin or NO synthase inhibitors, respectively.
Neg (NO) Negative_regulation (inhibitors) of alpha-chymotrypsin
5) Confidence 0.23 Published 1995 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 7600457 Disease Relevance 0 Pain Relevance 0.08
Nasobiliary bile showed either a rapid (median NT, 3 days) or a slow (median NT, 22 days) NT, depending on whether chymotrypsin activity was absent or present (p < 0.05).
Spec (whether) Negative_regulation (present) of chymotrypsin in bile associated with bile
6) Confidence 0.23 Published 1993 Journal Scand. J. Gastroenterol. Section Abstract Doc Link 8235437 Disease Relevance 0.20 Pain Relevance 0.46
In stimulatory doses of capsaicin treated rats, we observed the decrease in pancreatic amylase and fecal chymotrypsin activity, as well as, the drop in DNA synthesis.
Negative_regulation (decrease) of chymotrypsin associated with qutenza
7) Confidence 0.19 Published 2001 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 11787767 Disease Relevance 1.19 Pain Relevance 0.61
Nicotine-induced relaxation of adult duodenum was significantly inhibited by preincubation with alpha-chymotrypsin, a proteolytic enzyme, and a combination of nucleotide pyrophosphatase and 8-phenyltheophylline, a P1 purinoceptor antagonist.
Negative_regulation (antagonist) of alpha-chymotrypsin in duodenum associated with antagonist and nicotine
8) Confidence 0.14 Published 1994 Journal Eur. J. Pharmacol. Section Abstract Doc Link 8137872 Disease Relevance 0 Pain Relevance 0.65
There were no significant differences between cisapride and placebo periods in nutritional status, x-ray scores, pulmonary function, food intake (fat, protein, calories), stool size and consistency, and fecal losses of fat, bile acids, chymotrypsin, and calories.
Negative_regulation (losses) of chymotrypsin in fat associated with bile
9) Confidence 0.13 Published 1990 Journal J. Pediatr. Section Abstract Doc Link 2231217 Disease Relevance 1.65 Pain Relevance 0.29
The NANC excitation is more sensitive than the NANC inhibition to the action of catecholamines, reserpine, 6-hydroxydopamine, chymotrypsin, prednisolon, bacitracin, opioids, free oxygen species and low concentration of local anesthetics.
Negative_regulation (inhibition) of chymotrypsin associated with catecholamine, opioid and local anesthetic
10) Confidence 0.02 Published 1993 Journal Acta Neurobiol Exp (Wars) Section Abstract Doc Link 8391198 Disease Relevance 0 Pain Relevance 0.59
Several trypsin inhibitors and chymotrypsin inhibitor have been isolated (22-25).
Negative_regulation (inhibitor) of chymotrypsin
11) Confidence 0.02 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2877244 Disease Relevance 0.60 Pain Relevance 0.06
As a result of the covalent attachment of cysteine to polycarbophil, the inhibitory effect of the polymer towards carboxypeptidase A, carboxypeptidase B and chymotrypsin could be significantly improved.
Negative_regulation (effect) of chymotrypsin
12) Confidence 0.01 Published 2008 Journal Indian Journal of Pharmaceutical Sciences Section Body Doc Link PMC2792531 Disease Relevance 0 Pain Relevance 0.03
N-substituted isatins containing complex substituents effectively inhibited human serine proteases: chymotrypsin, leukocyte elastase and plasmin (Shuttleworth et al 2000).


Negative_regulation (inhibited) of chymotrypsin in leukocyte
13) Confidence 0.01 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0.61 Pain Relevance 0.04
Simple N-substituted isatin analogue, N-carbobenzyloxy isatin, acted as a slow binding inhibitor of chymotrypsin but not of porcine elastase (Iyer and Hanna 1995).
Negative_regulation (inhibitor) of chymotrypsin
14) Confidence 0.01 Published 2007 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721300 Disease Relevance 0.62 Pain Relevance 0.03
Initial studies of the inhibition of chymotrypsin by 3-benzyl-6-chloro-2-pyrone were interpreted as demonstrating suicide inhibition [33].
Negative_regulation (inhibition) of chymotrypsin associated with suicidal behaviour
15) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.19 Pain Relevance 0.04
Compound 2 is a prototype haloenol lactone developed by Katzenellenbogen and coworkers as an inhibitor of chymotrypsin, although it is not highly selective [9].
Negative_regulation (inhibitor) of chymotrypsin
16) Confidence 0.01 Published 2004 Journal BMC Pharmacol Section Body Doc Link PMC406500 Disease Relevance 0.15 Pain Relevance 0.13
Fecal chymotrypsin was diminished in all patients prior to intervention (1.9 +/- 0.7 U/g), and did not normalize after ductal drainage in any subject.
Negative_regulation (diminished) of chymotrypsin
17) Confidence 0.01 Published 2002 Journal World J Surg Section Abstract Doc Link 11865345 Disease Relevance 0.77 Pain Relevance 0.43
RESULTS: The transcription rates of three positive acute phase genes--chymotrypsin inhibitor, inter-alpha-trypsin inhibitor and beta-fibrinogen--increased seven-, six-, and twofold, respectively (P < 0.05), and the transcription rate of albumin, a negative acute phase gene, decreased to 34% of baseline (P < 0.01) during the 2.5 h of anesthesia and surgical stress.
Negative_regulation (inhibitor) of chymotrypsin
18) Confidence 0.00 Published 1993 Journal Anesthesiology Section Body Doc Link 7505533 Disease Relevance 0.15 Pain Relevance 0

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