INT219929

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.90
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)
Bmpr2 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 5 5.00 Very Low Very Low Very Low
Buprenorphine 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
cytokine 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteogenic Sarcomas 3 99.28 Very High Very High Very High
Malignant Neoplastic Disease 6 97.44 Very High Very High Very High
Calcification 2 80.60 Quite High
Fracture Healing 32 74.96 Quite High
Metastasis 1 72.24 Quite High
Closed Fractures 2 54.56 Quite High
Soft Tissue Injuries 1 32.76 Quite Low
Cancer 1 32.56 Quite Low
Injury 22 25.36 Quite Low
Tibial Fractures 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanism of the osteogenic effect of Rhizoma Drynariae can be partially explained by the activation of BMP-2 gene expression through the HMG-CoA reductase inhibition effect of naringin.
Positive_regulation (activation) of Gene_expression (expression) of BMP-2 gene
1) Confidence 0.15 Published 2007 Journal Chin Med Section Body Doc Link PMC2206024 Disease Relevance 0.08 Pain Relevance 0
It is possible that orcinol glucoside also affects the redox reaction of the HMG-CoA transformation to mevalonate and triggers the BMP-2 gene expression.
Positive_regulation (triggers) of Gene_expression (expression) of BMP-2 gene
2) Confidence 0.15 Published 2007 Journal Chin Med Section Body Doc Link PMC2206024 Disease Relevance 0.06 Pain Relevance 0
Multiple studies have questioned the impact of excess BMP-2 production in patients with osteosarcoma.
Positive_regulation (excess) of Gene_expression (production) of BMP-2 associated with osteogenic sarcomas
3) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.76 Pain Relevance 0

General Comments

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