INT219929

Context Info Confidence 0.15 First Reported 2007 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.90 Pain Relevance 0

plasma membrane (Bmpr2) kinase activity (Bmpr2) cytoplasm (Bmpr2)

Bmpr2 (Mus musculus)

Pain Link Frequency Relevance Heat Pain 5 5.00 Buprenorphine 4 5.00 imagery 3 5.00 Arthritis 2 5.00 cytokine 1 5.00 Inflammatory response 1 5.00

Disease Link Frequency Relevance Heat Osteogenic Sarcomas 3 99.28 Malignant Neoplastic Disease 6 97.44 Calcification 2 80.60 Fracture Healing 32 74.96 Metastasis 1 72.24 Closed Fractures 2 54.56 Soft Tissue Injuries 1 32.76 Cancer 1 32.56 Injury 22 25.36 Tibial Fractures 12 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mechanism of the osteogenic effect of Rhizoma Drynariae can be partially explained by the activation of BMP-2 gene expression through the HMG-CoA reductase inhibition effect of naringin.

Positive_regulation (activation) of Gene_expression (expression) of BMP-2 gene

1) Confidence 0.15 Published 2007 Journal Chin Med Section Body Doc Link PMC2206024 Disease Relevance 0.08 Pain Relevance 0

It is possible that orcinol glucoside also affects the redox reaction of the HMG-CoA transformation to mevalonate and triggers the BMP-2 gene expression.

Positive_regulation (triggers) of Gene_expression (expression) of BMP-2 gene

2) Confidence 0.15 Published 2007 Journal Chin Med Section Body Doc Link PMC2206024 Disease Relevance 0.06 Pain Relevance 0

Multiple studies have questioned the impact of excess BMP-2 production in patients with osteosarcoma.

Positive_regulation (excess) of Gene_expression (production) of BMP-2 associated with osteogenic sarcomas

3) Confidence 0.15 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2721393 Disease Relevance 0.76 Pain Relevance 0

General Comments

This test has worked.