INT219950

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 3
Disease Relevance 1.32
Pain Relevance 1.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SRC) cytoplasm (SRC) cytosol (SRC)
signal transduction (SRC) cell adhesion (SRC) nucleus (SRC)
SRC (Homo sapiens)
Pain Link Frequency Relevance Heat
mu opioid receptor 10 98.96 Very High Very High Very High
opiate 18 80.56 Quite High
amygdala 22 76.68 Quite High
palliative 4 76.08 Quite High
Opioid 10 71.72 Quite High
antagonist 20 65.00 Quite High
narcan 2 42.72 Quite Low
Pain management 2 24.56 Low Low
analgesia 4 22.40 Low Low
Breakthrough pain 2 20.56 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 18 96.16 Very High Very High Very High
Personality Disorder 15 94.00 High High
Cognitive Disorder 37 88.96 High High
Antisocial Personality Disorder 10 76.64 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 74.68 Quite High
Cancer 12 74.44 Quite High
Constipation 2 72.56 Quite High
Disease 4 64.24 Quite High
Pain 36 24.56 Low Low
Attention Deficit Hyperactivity Disorder 5 22.96 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
Negative_regulation (inhibits) of Gene_expression (activation) of Src associated with mu opioid receptor
1) Confidence 0.29 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.34 Pain Relevance 0.56
MNTX inhibits the mu opioid receptor and stimulates tyrosine phosphatase activity which inhibits VEGF-induced Src activation and Src-regulated PI3 kinase and mTOR Complex 2-mediated Akt activation.
Negative_regulation (inhibits) of Gene_expression (kinase) of Src-regulated associated with mu opioid receptor
2) Confidence 0.29 Published 2010 Journal J Angiogenes Res Section Body Doc Link PMC2831839 Disease Relevance 0.35 Pain Relevance 0.56
His SRC responses to negative emotional expressions were reduced.
Negative_regulation (reduced) of Gene_expression (responses) of SRC
3) Confidence 0.15 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC2206036 Disease Relevance 0.63 Pain Relevance 0.04

General Comments

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