INT21999

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.30
First Reported 1990
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 3.26
Pain Relevance 1.84

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (IGHG3)
Anatomy Link Frequency
plasma 2
accessory cells 2
B-cell 2
cerebrospinal fluid 2
lymphocytes 2
IGHG3 (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 8 100.00 Very High Very High Very High
Morphine 8 100.00 Very High Very High Very High
cytokine 12 99.00 Very High Very High Very High
Inflammation 29 96.40 Very High Very High Very High
metalloproteinase 1 95.32 Very High Very High Very High
Neuritis 4 91.80 High High
Multiple sclerosis 4 91.28 High High
intrathecal 1 82.04 Quite High
fibrosis 41 52.24 Quite High
rheumatoid arthritis 1 16.76 Low Low
Disease Link Frequency Relevance Heat
Pancreatitis 169 96.56 Very High Very High Very High
INFLAMMATION 19 96.40 Very High Very High Very High
Pancreatic Cancer 16 96.16 Very High Very High Very High
Congenital Anomalies 5 95.68 Very High Very High Very High
Optic Neuritis 4 92.04 High High
Demyelinating Disease 4 91.28 High High
Malaria 71 89.60 High High
Bites And Stings 6 87.76 High High
Disease 49 86.88 High High
Apoptosis 18 84.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
At concentrations relevant to those found in plasma, morphine and cocaine did not affect PWM-stimulated IgG synthesis in vitro.
Neg (not) Regulation (affect) of Gene_expression (synthesis) of IgG in plasma associated with cocaine and morphine
1) Confidence 0.30 Published 1990 Journal Life Sci. Section Abstract Doc Link 2233132 Disease Relevance 0.07 Pain Relevance 0.51
(i) It was dependent on serum IgG1 and IgG3 isotypes, which mediate antibody interactions with accessory cells via Fc?
Regulation (dependent) of Gene_expression (isotypes) of IgG3 in accessory cells
2) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2845614 Disease Relevance 0.14 Pain Relevance 0.04
No changes in IgG2 and IgG4 responses were evident in the control arm.
Neg (No) Regulation (changes) of Gene_expression (responses) of IgG4 in arm
3) Confidence 0.30 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2764341 Disease Relevance 0.08 Pain Relevance 0
Effects of cocaine and morphine on IgG production by human peripheral blood lymphocytes in vitro.
Regulation (Effects) of Gene_expression (production) of IgG in lymphocytes associated with morphine and cocaine
4) Confidence 0.13 Published 1990 Journal Life Sci. Section Title Doc Link 2233132 Disease Relevance 0.10 Pain Relevance 0.51
However, the sensitivity of elevated serum IgG4 levels is 63%–68% in other reports.15,16,49 Elevation of serum IgG4 levels has been reported in a patient with pancreatic cancer.50

Radiological findings

Regulation (sensitivity) of Gene_expression (levels) of IgG4 associated with pancreatic cancer
5) Confidence 0.05 Published 2006 Journal J Gastroenterol Section Body Doc Link PMC2780632 Disease Relevance 1.20 Pain Relevance 0.03
The lack of a persistent effect on cerebrospinal fluid leucocyte recruitment and MMP-9 activity, despite changes in IgG synthesis, T-cell activation, and cytokine production, suggests that modulation of the function of inflammatory cells may contribute to the clinical efficacy of oral high-dose methylprednisolone treatment in optic neuritis and multiple sclerosis.
Regulation (changes) of Gene_expression (synthesis) of IgG in cerebrospinal fluid associated with multiple sclerosis, inflammation, optic neuritis, neuritis and cytokine
6) Confidence 0.04 Published 2000 Journal Eur. J. Neurol. Section Abstract Doc Link 10886311 Disease Relevance 0.77 Pain Relevance 0.64
Despite the fact that the extensive serologic overlap occurring between CHIKV and ONNV precludes any definitive interpretation of the results as to which virus may have been responsible for the production of the IgG antibodies in 90.5% of the sera [28], the overall optical density of the CHIKV ELISA was three to eleven times more than that of ONNV (data not shown).
Regulation (responsible) of Gene_expression (production) of IgG
7) Confidence 0.01 Published 2010 Journal BMC Res Notes Section Body Doc Link PMC2883987 Disease Relevance 0.56 Pain Relevance 0
Changes in IgG production were a direct result of an impaired B-cell response.
Regulation (Changes) of Gene_expression (production) of IgG in B-cell
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2695011 Disease Relevance 0.34 Pain Relevance 0.11

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox