INT220

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Context Info
Confidence 0.59
First Reported 1976
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 16
Total Number 16
Disease Relevance 2.94
Pain Relevance 8.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Ddc) cellular amino acid metabolic process (Ddc) cytoplasm (Ddc)
Anatomy Link Frequency
brain 2
brain stem 2
hypothalamus 2
dorsal 1
corpus striatum 1
Ddc (Mus musculus)
Pain Link Frequency Relevance Heat
midbrain 47 100.00 Very High Very High Very High
Dopamine 174 99.64 Very High Very High Very High
noradrenaline 16 99.48 Very High Very High Very High
Hippocampus 7 99.48 Very High Very High Very High
Clonidine 22 98.92 Very High Very High Very High
Catecholamine 16 98.66 Very High Very High Very High
Hyperalgesia 8 98.34 Very High Very High Very High
Limbic system 3 97.68 Very High Very High Very High
Morphine 14 97.60 Very High Very High Very High
Serotonin 42 97.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 5 99.86 Very High Very High Very High
Hypothermia 1 99.12 Very High Very High Very High
Disease 92 98.68 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 164 98.52 Very High Very High Very High
Hyperalgesia 8 98.34 Very High Very High Very High
Nociception 4 95.84 Very High Very High Very High
Heart Rate Under Development 1 90.56 High High
Depression 10 90.44 High High
Hepatotoxicity 2 86.88 High High
Pain 2 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Ethanol alone (2.36 g/kg i.p.) did not significantly affect the amount of Dopa accumulating in various mouse brain regions (limbic system, corpus striatum, hemispheres and brain stem) during 30 min following administration of 3-hydroxybenzylhydrazine (NSD 1015), an inhibitor of aromatic amino-acid decarboxylase.
Negative_regulation (inhibitor) of aromatic amino-acid decarboxylase in brain stem associated with limbic system
1) Confidence 0.59 Published 1977 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 403547 Disease Relevance 0.10 Pain Relevance 0.42
The concentration of 5-hydroxytryptophan (5-HTP), 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT was measured in hypothalamus, hippocampus and frontal cortex after inhibition of the aromatic amino acid decarboxylase activity with m-hydroxybenzylhydrazine (NSD 1015).
Negative_regulation (inhibition) of aromatic amino acid decarboxylase in frontal cortex associated with urological neuroanatomy and hippocampus
2) Confidence 0.59 Published 2002 Journal Life Sci. Section Abstract Doc Link 12377268 Disease Relevance 0.10 Pain Relevance 0.55
The accumulation of Dopa, as induced by the inhibitor of aromatic amino acid decarboxylase, NSD 1015, was measured in parallel in two dopamine-rich regions, i.e. the limbic system and the corpus striatum, and in two noradrenaline-rich regions, i.e. the neocortex and the lower brain stem.
Negative_regulation (inhibitor) of aromatic amino acid decarboxylase in brain stem associated with dopamine, noradrenaline and limbic system
3) Confidence 0.57 Published 1976 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 181681 Disease Relevance 0.06 Pain Relevance 0.62
In the same dose, and at the same time interval as the behavioural stimulation was obtained, morphine did not significantly affect the in vivo rate of tyrosine hydroxylation in two dopamine (DA)-rich mouse brain regions, the corpus striatum and in the limbic system, or in the noradrenaline (NA)-rich, but DA-poor hemispheres, measured as the Dopa-accumulation during 30 min after inhibition of aromatic amino-acid decarboxylase by 3-hydroxybenzylhydrazine (NSD 1015) 150 mg/kg.
Negative_regulation (inhibition) of aromatic amino-acid decarboxylase in corpus striatum associated with dopamine, noradrenaline, limbic system and morphine
4) Confidence 0.53 Published 1978 Journal J. Neural Transm. Section Abstract Doc Link 690627 Disease Relevance 0 Pain Relevance 1.39
The above treatment with clonidine significantly reduced the accumulation of dopa after inhibition of central aromatic L-amino acid decarboxylase both in the noradrenaline (NA) rich neocortex and the dopamine-rich neocortex and the dopamine-rich corpus striatum, whereas the dopa accumulation in the limbic brain regions was not significantly affected. l-Amphetamine, 0.75 mg/kg i.p., did not by itself significantly affect the dopa accumulation, but reduced the clonidine-induced effects.
Negative_regulation (inhibition) of L-amino acid decarboxylase in brain associated with dopamine, noradrenaline and clonidine
5) Confidence 0.51 Published 1980 Journal J. Neural Transm. Section Abstract Doc Link 7359121 Disease Relevance 0.16 Pain Relevance 0.97
Bulbectomy resulted in a moderate decrease (-28%) in DOPA decarboxylase activity 14 days after surgery, which returned to normal by 30 days.
Negative_regulation (decrease) of DOPA
6) Confidence 0.45 Published 1980 Journal Brain Res. Section Abstract Doc Link 6250675 Disease Relevance 0 Pain Relevance 0.33
Further evidence for dopamine involvement in pregnancy block is demonstrated by showing DOPA accumulation in the medio-basal hypothalamus following exposure to male urinary pheromones after dihydroxybenzylhydrazine (DHBH) administration, which blocks the enzyme DOPA-decarboxylase.
Negative_regulation (blocks) of DOPA-decarboxylase in hypothalamus associated with dopamine
7) Confidence 0.39 Published 1989 Journal J. Reprod. Fertil. Section Abstract Doc Link 2513390 Disease Relevance 0 Pain Relevance 0.33
The effects of morphine and AOAA on the turnover of brain catecholamines (CA) were determined by measuring both the accumulation of dopa after inhibition of central aromatic L-amino acid decarboxylase and by measuring the depletion of noradrenaline (NA) after inhibition of tyrosine hydroxylase by alpha-methyltyrosine (alpha-MT).
Negative_regulation (inhibition) of L-amino acid decarboxylase in brain associated with catecholamine, noradrenaline and morphine
8) Confidence 0.38 Published 1977 Journal J. Neural Transm. Section Abstract Doc Link 18553 Disease Relevance 0 Pain Relevance 0.95
L-DOPA induced hyperalgesia occurred after conversion to dopamine because co-administration of benserazide, a DOPA decarboxylase inhibitor, completely abolished the L-DOPA-induced hyperalgesia.
Negative_regulation (inhibitor) of DOPA associated with dopamine and hyperalgesia
9) Confidence 0.33 Published 2006 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 17141847 Disease Relevance 0.86 Pain Relevance 1.19
In order to address whether CIT administration renders 5-HT stores more sensitive to the suppression of 5-HT synthesis, we also examined forebrain 5-HT and 5-HIAA content in CIT- and vehicle-treated mice following acute inhibition of amino acid decarboxylase.


Negative_regulation (inhibition) of amino acid decarboxylase in forebrain
10) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2728775 Disease Relevance 0 Pain Relevance 0.13
The concentration of 5-hydroxytryptophan (5-HTP), 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT was measured in hypothalamus, hippocampus and frontal cortex after inhibition of the aromatic amino acid decarboxylase activity with m-hydroxybenzylhydrazine (NSD 1015).
Negative_regulation (inhibition) of aromatic amino acid decarboxylase in hippocampus associated with urological neuroanatomy and hippocampus
11) Confidence 0.20 Published 2002 Journal Life Sci. Section Abstract Doc Link 12377268 Disease Relevance 0.10 Pain Relevance 0.55
The concentration of 5-hydroxytryptophan (5-HTP), 5-hydroxyindoleacetic acid (5-HIAA) and 5-HT was measured in hypothalamus, hippocampus and frontal cortex after inhibition of the aromatic amino acid decarboxylase activity with m-hydroxybenzylhydrazine (NSD 1015).
Negative_regulation (inhibition) of aromatic amino acid decarboxylase in hypothalamus associated with urological neuroanatomy and hippocampus
12) Confidence 0.20 Published 2002 Journal Life Sci. Section Abstract Doc Link 12377268 Disease Relevance 0.10 Pain Relevance 0.55
Two catechol- O-methyltransferase (COMT) inhibitors, entacapone and tolcapone, were developed during the 1990's to be used as adjuncts to levodopa (LD) - dopa decarboxylase (DDC) inhibitors in the treatment of Parkinson's disease (PD).
Negative_regulation (inhibitors) of dopa decarboxylase associated with disease
13) Confidence 0.13 Published 2004 Journal J Neural Transm Section Abstract Doc Link 15340869 Disease Relevance 0.28 Pain Relevance 0.04
The effect of L-DOPA on the heart rate and baroreceptor reflexes is reversed by preliminary inhibition of peripheral DOPA-decarboxylase with benserazide (30 mg/kg).
Negative_regulation (inhibition) of DOPA-decarboxylase in heart
14) Confidence 0.11 Published 1982 Journal Farmakol Toksikol Section Abstract Doc Link 7151995 Disease Relevance 0.26 Pain Relevance 0
One is characterized by DOPA decarboxylase decrease involving both the nigrostriatal and the mesolimbic compartments, and is responsible for the moderate DA decrease in the dorsal striatum.
Negative_regulation (decrease) of DOPA decarboxylase in dorsal
15) Confidence 0.04 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2978035 Disease Relevance 0.54 Pain Relevance 0.09
DOPA decarboxylase activity was found to be increased in the midbrain of children and decreased in prefrontal cortex of adults with ADHD compared to controls [52,53].
Negative_regulation (decreased) of DOPA decarboxylase in cortex associated with midbrain and attention deficit hyperactivity disorder
16) Confidence 0.03 Published 2005 Journal Behav Brain Funct Section Body Doc Link PMC1180819 Disease Relevance 0.38 Pain Relevance 0.56

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