INT22000

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Context Info
Confidence 0.70
First Reported 1987
Last Reported 2008
Negated 2
Speculated 0
Reported most in Abstract
Documents 25
Total Number 25
Disease Relevance 14.82
Pain Relevance 13.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Sst) extracellular region (Sst)
Anatomy Link Frequency
spinal cord 3
macrophages 2
epithelial cells 2
plasma 1
striatum 1
Sst (Mus musculus)
Pain Link Frequency Relevance Heat
Somatostatin 274 100.00 Very High Very High Very High
substance P 24 100.00 Very High Very High Very High
Glutamate 10 100.00 Very High Very High Very High
bradykinin 5 100.00 Very High Very High Very High
Neuropeptide 16 99.98 Very High Very High Very High
Antinociceptive 8 99.96 Very High Very High Very High
agonist 48 99.84 Very High Very High Very High
Inflammation 406 99.80 Very High Very High Very High
GABA receptor 1 99.60 Very High Very High Very High
Serotonin 2 99.22 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 20 99.96 Very High Very High Very High
INFLAMMATION 441 99.80 Very High Very High Very High
Schistosomiasis 2 99.62 Very High Very High Very High
Obesity 64 99.40 Very High Very High Very High
Carcinoid 20 99.40 Very High Very High Very High
Gallbladder Neoplasms 94 99.28 Very High Very High Very High
Granuloma 1 99.16 Very High Very High Very High
Ganglion Cysts 73 98.82 Very High Very High Very High
Sprains And Strains 8 98.42 Very High Very High Very High
Diabetes Mellitus 39 98.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
During schistosomiasis, the neuropeptide somatostatin is generated within inflammatory granulomas.
Positive_regulation (generated) of somatostatin associated with inflammation, somatostatin, neuropeptide, granuloma and schistosomiasis
1) Confidence 0.70 Published 2002 Journal Int. J. Parasitol. Section Abstract Doc Link 12204231 Disease Relevance 1.04 Pain Relevance 0.38
Furthermore, mexiletine also significantly inhibited the intensity of somatostatin (SST)-induced antinociceptive effect of mexiletine in diabetic mice involves the inhibition of SP- and SST-mediated nociceptive transmission in the spinal cord.
Positive_regulation (-induced) of somatostatin in spinal cord associated with nociception, diabetes mellitus, somatostatin, mexiletine, antinociceptive, spinal cord and substance p
2) Confidence 0.50 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 7686682 Disease Relevance 1.22 Pain Relevance 0.81
However, the effect of SST on the growth of gallbladder cancer cells was observed at fairly high SST concentration (i.e., 75 ?
Positive_regulation (effect) of SST associated with gallbladder neoplasms and somatostatin
3) Confidence 0.50 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.65 Pain Relevance 0.47
In contrast, db/db mice of both C57BL/6J and C57BL/KsJ strains exhibited alterations in a total of four peptides in three brain areas: lower concentration of somatostatin-LI in median eminence, higher Met-enkephalin-LI in dorsal vagal complex of the medulla oblongata, higher substance P-LI and lower vasoactive intestinal polypeptide (VIP)-LI in amygdala.
Positive_regulation (concentration) of somatostatin in brain associated with medulla, somatostatin, enkephalin, sprains and strains, amygdala and substance p
4) Confidence 0.49 Published 1990 Journal Metab. Clin. Exp. Section Abstract Doc Link 2233277 Disease Relevance 0.78 Pain Relevance 0.58
Furthermore, mexiletine also significantly inhibited the intensity of somatostatin (SST)-induced antinociceptive effect of mexiletine in diabetic mice involves the inhibition of SP- and SST-mediated nociceptive transmission in the spinal cord.
Positive_regulation (-induced) of SST in spinal cord associated with nociception, diabetes mellitus, somatostatin, mexiletine, antinociceptive, spinal cord and substance p
5) Confidence 0.44 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 7686682 Disease Relevance 1.21 Pain Relevance 0.81
The ratio of cells in the S phase increased 12 h after treatment with SST and was significantly higher than that for the control group 24 h after SST treatment (Figure 1A).
Positive_regulation (increased) of SST associated with somatostatin
6) Confidence 0.44 Published 2007 Journal BMC Cancer Section Body Doc Link PMC1931603 Disease Relevance 0.55 Pain Relevance 0.34
These results indicate the possibility that TD feeding may produce an increased behavioral response to SP and SST through an enhanced sensitivity of neurokinin-1 and SST receptors in the spinal cord.
Positive_regulation (increased) of SST in spinal cord associated with somatostatin, spinal cord and substance p
7) Confidence 0.41 Published 2001 Journal Life Sci. Section Abstract Doc Link 11508348 Disease Relevance 0.15 Pain Relevance 1.08
Twelve weeks after infection of C57BL/6J mice with LP-BM5, significant (50-60%) reductions in Met-enkephalin and substance P levels were observed in the striatum, whereas somatostatin levels were unchanged.
Neg (unchanged) Positive_regulation (unchanged) of somatostatin in striatum associated with somatostatin, enkephalin, infection and substance p
8) Confidence 0.40 Published 1995 Journal J. Neurochem. Section Abstract Doc Link 7534338 Disease Relevance 0.49 Pain Relevance 0.43
The duration of the somatostatin-, bradykinin- or prostaglandin F2alpha-induced nociceptive response was significantly less in diabetic mice than in non-diabetic mice.
Positive_regulation (induced) of somatostatin associated with nociception, diabetes mellitus, somatostatin and bradykinin
9) Confidence 0.40 Published 1999 Journal Eur. J. Pharmacol. Section Abstract Doc Link 10225369 Disease Relevance 0.83 Pain Relevance 0.40
No leucine-enkephalin immunoreactivity was seen in dorsal root ganglion cultures; a considerable proportion of the processes were immunoreactive for substance P or somatostatin.
Positive_regulation (immunoreactive) of somatostatin in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion, somatostatin, enkephalin and substance p
10) Confidence 0.39 Published 1993 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 8135129 Disease Relevance 0.25 Pain Relevance 0.97
Since their single administration after the development of the inflammatory reactions also inhibited carbachol-induced bronchoconstriction, somatostatin sst(4) receptor activation on bronchial smooth muscle cells is likely to be involved in their anti-hyperreactivity effect.
Positive_regulation (activation) of somatostatin in smooth muscle cells associated with inflammation and somatostatin
11) Confidence 0.37 Published 2008 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17961545 Disease Relevance 0.72 Pain Relevance 0.62
Inflammation markedly elevated lung and plasma somatostatin concentrations in TRPV1(+/+) but not TRPV1(-/-) animals.
Positive_regulation (elevated) of somatostatin in plasma associated with inflammation and somatostatin
12) Confidence 0.37 Published 2007 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 17237150 Disease Relevance 0.92 Pain Relevance 0.53
An increase in glutamate and somatostatin binding could contribute to the enhanced excitability in the-mu-opioid receptor knockout mice.
Positive_regulation (increase) of somatostatin associated with targeted disruption, glutamate, somatostatin and opioid receptor
13) Confidence 0.34 Published 2004 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 14963640 Disease Relevance 0.34 Pain Relevance 0.56
Among mediators of neurotransmission, multiple glutamate receptors (Gria3, Gria4, Grik1), a GABA transporter (Slc6a1), a serotonin receptor (Htr3a) and the neuropeptide somatostatin are increased, while a GABA receptor (Gabra2) and neuropeptides with specific sensory roles (Galanin, Adcyap1/PACAP) are decreased.
Positive_regulation (increased) of somatostatin associated with gaba, gaba receptor, glutamate receptor, somatostatin, neuropeptide and serotonin
14) Confidence 0.17 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.35 Pain Relevance 0.37
Inflammation markedly elevated lung and plasma somatostatin concentrations in TRPV1(+/+) but not TRPV1(-/-) animals.
Positive_regulation (elevated) of somatostatin in lung associated with inflammation and somatostatin
15) Confidence 0.12 Published 2007 Journal Am. J. Physiol. Lung Cell Mol. Physiol. Section Abstract Doc Link 17237150 Disease Relevance 0.92 Pain Relevance 0.53
In patient 2, ApEn was 1.256 before removal of the carcinoid, and after surgery and under somatostatin analog treatment ApEn was still increased to 0.686 (median normal for women 0.400, 95% confidence interval 0.300–0.440).
Positive_regulation (increased) of somatostatin associated with carcinoid and somatostatin
16) Confidence 0.07 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.38 Pain Relevance 0.05
For example, somatostatin receptor-2 is the most abundant of the somatostatin receptors expressed by inflammatory cells [42]; activation of somatostatin receptors with somatostatin or agonists can downregulate proinflammatory cytokine secretion by human macrophages, epithelial cells or rodent microglia [8,29,46,169].
Positive_regulation (activation) of somatostatin in epithelial cells associated with inflammation, agonist, somatostatin and cytokine
17) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.90 Pain Relevance 0.86
For example, somatostatin receptor-2 is the most abundant of the somatostatin receptors expressed by inflammatory cells [42]; activation of somatostatin receptors with somatostatin or agonists can downregulate proinflammatory cytokine secretion by human macrophages, epithelial cells or rodent microglia [8,29,46,169].
Positive_regulation (activation) of somatostatin in epithelial cells associated with inflammation, agonist, somatostatin and cytokine
18) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2644496 Disease Relevance 0.90 Pain Relevance 0.86
Cafeteria diet-induced obese rats have been shown to have increased somatostatin protein content and gene expression in the periventricular nucleus [171].
Positive_regulation (increased) of somatostatin in periventricular nucleus associated with obesity and somatostatin
19) Confidence 0.03 Published 2007 Journal Nutr Metab (Lond) Section Body Doc Link PMC2018708 Disease Relevance 0.41 Pain Relevance 0.21
A histogram of the SS IFR shows that PPCs always had a large peak near the 0 firing rate due to the long pauses in their SS firing [Figures 1A(III),B(III)] and usually (61%) had a clearly visible bimodal distribution [Figure 1A(III)].
Positive_regulation (pauses) of SS
20) Confidence 0.03 Published 2008 Journal Frontiers in Systems Neuroscience Section Body Doc Link PMC2671936 Disease Relevance 0 Pain Relevance 0

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