INT22003

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 25
Total Number 26
Disease Relevance 6.23
Pain Relevance 12.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cpe) extracellular space (Cpe) Golgi apparatus (Cpe)
Anatomy Link Frequency
brain 2
margins 1
tail 1
spinal cord 1
vas deferens 1
Cpe (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Enkephalin 113 100.00 Very High Very High Very High
headache 27 100.00 Very High Very High Very High
medulla 15 100.00 Very High Very High Very High
Triptan 1 100.00 Very High Very High Very High
analgesia 4 99.98 Very High Very High Very High
cva 20 99.92 Very High Very High Very High
Cluster headache 9 99.84 Very High Very High Very High
Morphine 2 99.78 Very High Very High Very High
Spinal cord 4 99.00 Very High Very High Very High
Neuropeptide 8 98.60 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperplasia 100 100.00 Very High Very High Very High
Heart Rate Under Development 37 100.00 Very High Very High Very High
Paroxysmal Hemicrania 18 100.00 Very High Very High Very High
Pulmonary Embolism 20 99.92 Very High Very High Very High
Cluster Headache 9 99.84 Very High Very High Very High
Pneumonia 22 99.64 Very High Very High Very High
Headache 7 98.48 Very High Very High Very High
Arthropathy 5 97.62 Very High Very High Very High
Hypertrophy 2 96.00 Very High Very High Very High
Volume Depletion And Dehydration 3 94.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Several hours after insulin-induced reflex splanchnic stimulation, the levels of CPE activity in rat adrenal medulla are reduced to 40-60% of control.
Negative_regulation (reduced) of CPE in adrenal medulla associated with medulla
1) Confidence 0.58 Published 1990 Journal J. Neurochem. Section Abstract Doc Link 2370548 Disease Relevance 0.07 Pain Relevance 0.52
In every case 25 microM guanidinoethylmercaptosuccinic acid, an active site-directed inhibitor of carboxypeptidase H, completely inhibits the activity.
Negative_regulation (inhibitor) of carboxypeptidase H
2) Confidence 0.57 Published 1989 Journal Anal. Biochem. Section Abstract Doc Link 2658684 Disease Relevance 0 Pain Relevance 0
Evidence is discussed which illustrates how CPH can be inhibited and activated.
Negative_regulation (inhibited) of CPH
3) Confidence 0.57 Published 1988 Journal Cell. Mol. Neurobiol. Section Abstract Doc Link 3135937 Disease Relevance 0 Pain Relevance 0.17
3H-Guanidinoethylmercaptosuccinic acid (3H-GEMSA) a very selective inhibitor of enkephalin convertase, binds to the crude rat spinal cord homogenates saturably, reversibly and with high affinity.
Negative_regulation (inhibitor) of enkephalin convertase in spinal cord associated with enkephalin and spinal cord
4) Confidence 0.54 Published 1986 Journal Neuropeptides Section Abstract Doc Link 3102993 Disease Relevance 0 Pain Relevance 0.36
There are no changes in [3H] GEMSA binding in the supraoptic nucleus or magnocellular portion of the paraventricular nucleus of the hypothalamus under any of these conditions, suggesting that the alterations observed in the neurohypophysis result from an increased rate of loss of enkephalin convertase.
Negative_regulation (loss) of enkephalin convertase in hypothalamus associated with enkephalin
5) Confidence 0.52 Published 1985 Journal Endocrinology Section Abstract Doc Link 3928337 Disease Relevance 0.17 Pain Relevance 0.45
Depletion of carboxypeptidase E, a regulated secretory pathway sorting receptor, causes misrouting and constitutive secretion of proinsulin and proenkephalin, but not chromogranin A.
Negative_regulation (Depletion) of carboxypeptidase E associated with enkephalin
6) Confidence 0.46 Published 1998 Journal Endocrinology Section Title Doc Link 9529003 Disease Relevance 0 Pain Relevance 0.20
The therapeutic profile in CPH (indomethacin effect: ++; triptan effect: generally non-existent) is reversed in CH.
Negative_regulation (reversed) of CPH associated with cluster headache, triptan and headache
7) Confidence 0.42 Published 2010 Journal Funct. Neurol. Section Abstract Doc Link 20626997 Disease Relevance 1.71 Pain Relevance 2.09
These tests may be used to distinguish CPH and cluster headache clinically.
Negative_regulation (distinguish) of CPH associated with cluster headache and headache
8) Confidence 0.42 Published 1988 Journal Cephalalgia Section Abstract Doc Link 3197102 Disease Relevance 0.92 Pain Relevance 0.84
A sensitive radiometric assay for carboxypeptidase B-like enzymes has been developed using enkephalin convertase, an enkephalin synthesizing carboxypeptidase.
Negative_regulation (using) of enkephalin synthesizing carboxypeptidase associated with enkephalin
9) Confidence 0.37 Published 1984 Journal Life Sci. Section Abstract Doc Link 6420632 Disease Relevance 0 Pain Relevance 0.28
A sensitive radiometric assay for carboxypeptidase B-like enzymes has been developed using enkephalin convertase, an enkephalin synthesizing carboxypeptidase.
Negative_regulation (using) of enkephalin convertase associated with enkephalin
10) Confidence 0.37 Published 1984 Journal Life Sci. Section Abstract Doc Link 6420632 Disease Relevance 0 Pain Relevance 0.27
Adrenal carboxypeptidase E activity was also decreased after denervation.
Negative_regulation (decreased) of carboxypeptidase E
11) Confidence 0.32 Published 1993 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 8432002 Disease Relevance 0 Pain Relevance 0.90
Whereas these cells were depleted of CPE by greater than 85%, electron microscopy showed that they contain dense core secretory granules identical to wild-type Neuro-2a cells, indicating that CPE is not essential for granulogenesis.
Negative_regulation (depleted) of CPE in Neuro-2a
12) Confidence 0.30 Published 1998 Journal Endocrinology Section Abstract Doc Link 9529003 Disease Relevance 0 Pain Relevance 0
Additionally, the enkephalin-hydrolyzing aminopeptidase, endopeptidase-24.11 and peptidyl dipeptidase A in rat vas deferens were found to be inhibited maximally with 1 microM of amastatin, 1 microM of phosphoramidon and 1 microM of captopril, respectively.
Negative_regulation (inhibited) of enkephalin-hydrolyzing aminopeptidase in vas deferens associated with enkephalin
13) Confidence 0.22 Published 1986 Journal Jpn. J. Pharmacol. Section Abstract Doc Link 3540390 Disease Relevance 0 Pain Relevance 0.54
In this study, inhibition of carboxypeptidase H by its peptide products was investigated.
Negative_regulation (inhibition) of carboxypeptidase H
14) Confidence 0.21 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2887569 Disease Relevance 0 Pain Relevance 0.24
Product inhibition of carboxypeptidase H and perhaps other processing enzymes may serve to limit the maximum peptide concentration within the secretory vesicle.
Negative_regulation (inhibition) of carboxypeptidase H in vesicle
15) Confidence 0.21 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2887569 Disease Relevance 0 Pain Relevance 0.77
Product inhibition of carboxypeptidase H.
Negative_regulation (inhibition) of carboxypeptidase H
16) Confidence 0.21 Published 1987 Journal J. Biol. Chem. Section Title Doc Link 2887569 Disease Relevance 0 Pain Relevance 0.51
Thus, the products from one multivalent precursor molecule may equivalently inhibit carboxypeptidase H activity.
Spec (may) Negative_regulation (inhibit) of carboxypeptidase H
17) Confidence 0.21 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2887569 Disease Relevance 0 Pain Relevance 0.84
These levels of peptides are similar to known intragranular peptide concentrations indicating that product and feedback inhibition of carboxypeptidase H may play a role in the control of neuropeptide synthesis.
Negative_regulation (inhibition) of carboxypeptidase H associated with neuropeptide
18) Confidence 0.16 Published 1987 Journal J. Biol. Chem. Section Abstract Doc Link 2887569 Disease Relevance 0 Pain Relevance 0.90
Bony hypertrophy from facet arthrosis was not considered a potential confounder because arthrosis normally occurs on the anterior or posterior margins of the facet, not the superior and inferior surfaces used in the definition of CPH.
Negative_regulation (definition) of CPH in margins associated with hypertrophy, arthropathy and hyperplasia
19) Confidence 0.15 Published 2006 Journal Chiropr Osteopat Section Body Doc Link PMC1592100 Disease Relevance 1.05 Pain Relevance 0
Previous results have shown that the relative abundance of proenkephalin mRNA in the rat heart is comparable to the levels found in the brain; however, the extractable enkephalin-containing peptide levels are much lower in the heart.
Negative_regulation (lower) of enkephalin-containing peptide in brain associated with enkephalin
20) Confidence 0.08 Published 1990 Journal Mol. Endocrinol. Section Abstract Doc Link 2233751 Disease Relevance 0 Pain Relevance 0.10

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