INT220033

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Context Info
Confidence 0.05
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.52
Pain Relevance 0.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Casp3, Nos1) cytoplasm (Casp3, Nos1) cytosol (Casp3, Nos1)
nucleus (Casp3, Nos1) aging (Nos1) intracellular (Casp3)
Anatomy Link Frequency
dorsal horn 2
Casp3 (Rattus norvegicus)
Nos1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
intrathecal 16 100.00 Very High Very High Very High
ketamine 17 99.84 Very High Very High Very High
Pain 13 96.44 Very High Very High Very High
Dorsal horn neuron 1 95.72 Very High Very High Very High
antagonist 10 90.80 High High
Inflammation 4 88.28 High High
Dorsal horn 32 82.04 Quite High
Spinal cord 32 62.76 Quite High
Antinociceptive 4 57.76 Quite High
Calcitonin gene-related peptide 1 56.20 Quite High
Disease Link Frequency Relevance Heat
Pain 23 96.44 Very High Very High Very High
INFLAMMATION 4 88.28 High High
Disease 2 76.48 Quite High
Injury 5 71.20 Quite High
Nociception 6 66.20 Quite High
Frailty 1 63.04 Quite High
Arthritis 9 24.24 Low Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this regard, it is tempting to speculate that the decrease in nNOS expression induced by the intrathecal administration of CPP or ketamine could be related to the depressant action of these drugs on the activity of pain-transmitting dorsal horn neurons, but there are no conclusive data on this matter.
CPP Positive_regulation (induced) of Gene_expression (expression) of nNOS in dorsal horn associated with pain, ketamine, dorsal horn neuron and intrathecal
1) Confidence 0.05 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.52 Pain Relevance 0.72

General Comments

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