INT220035

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Context Info
Confidence 0.29
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.45
Pain Relevance 0.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Nos1, Nos2) cytoplasm (Nos1, Nos2) cytosol (Nos1, Nos2)
nucleus (Nos1, Nos2) mitochondrion (Nos1) peroxisome (Nos2)
Nos1 (Rattus norvegicus)
Nos2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ketamine 17 97.84 Very High Very High Very High
Spinal cord 32 94.88 High High
Lasting pain 9 90.20 High High
Pain 13 88.48 High High
nMDA receptor 17 87.20 High High
Dorsal horn 32 68.16 Quite High
antagonist 10 63.52 Quite High
intrathecal 16 60.36 Quite High
Antinociceptive 4 54.76 Quite High
Dorsal horn neuron 1 25.44 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 95.56 Very High Very High Very High
Pain 23 90.20 High High
Arthritis 9 88.88 High High
INFLAMMATION 4 6.12 Low Low
Nociception 6 5.00 Very Low Very Low Very Low
Hyperalgesia 5 5.00 Very Low Very Low Very Low
Injury 5 5.00 Very Low Very Low Very Low
Disease 2 5.00 Very Low Very Low Very Low
Neuropathic Pain 2 5.00 Very Low Very Low Very Low
Hypersensitivity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The apparent compensation for the decrease in nNOS by rapid increases in iNOS and eNOS that we observed after administering CPP or ketamine is expected to have a functional meaning because all NOS isoforms are involved in producing the pronociceptive mediator nitric oxide, which may be relevant to prolonged treatment of chronic pain conditions, such as arthritic pain, with drugs that block the NMDA receptor.
nNOS Positive_regulation (increases) of iNOS associated with pain, ketamine, nmda receptor, lasting pain and arthritis
1) Confidence 0.29 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206346 Disease Relevance 0.45 Pain Relevance 0.66

General Comments

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