INT22004

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Context Info
Confidence 0.49
First Reported 1984
Last Reported 2008
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 3.29
Pain Relevance 0.96

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
mast cell 4
capillary 2
IGHE (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammatory mediators 1 100.00 Very High Very High Very High
cva 3 98.78 Very High Very High Very High
cytokine 84 95.84 Very High Very High Very High
Central nervous system 1 85.56 High High
depression 1 84.44 Quite High
Multiple sclerosis 1 83.28 Quite High
Morphine 2 81.32 Quite High
Inflammation 24 80.72 Quite High
Sciatica 1 79.80 Quite High
opiate 1 79.68 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 27 100.00 Very High Very High Very High
Mycobacterial Infection 1 99.68 Very High Very High Very High
Opiate Addiction 1 99.58 Very High Very High Very High
Heart Rate Under Development 2 99.08 Very High Very High Very High
Asthma 112 97.72 Very High Very High Very High
Hypersensitivity 26 97.28 Very High Very High Very High
Anaphylaxis 7 97.24 Very High Very High Very High
Urticaria 53 93.80 High High
Death 1 93.12 High High
Hypoxia 1 89.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunoassays employing substituted ammonium compounds other than neuromuscular blocking drugs to increase the detection of IgE antibodies to these drugs.
Positive_regulation (increase) of IgE Binding (detection) of
1) Confidence 0.49 Published 1990 Journal Mol. Immunol. Section Title Doc Link 2233754 Disease Relevance 0.17 Pain Relevance 0.14
CONCLUSION: Serum levels of IgE antibodies associated with allergy towards NMBAs increase significantly in sensitized patients after exposure to cough syrup containing pholcodine.
Positive_regulation (increase) of IgE Binding (associated) of
2) Confidence 0.46 Published 2007 Journal Allergy Section Body Doc Link 17983379 Disease Relevance 0.07 Pain Relevance 0
Subjects who were positive for IgE specific for three superantigens did not differ from those who were negative for each superantigen-specific IgE in terms of gender ratio, age, and the duration of urticaria.
Positive_regulation (positive) of IgE Binding (specific) of associated with urticaria
3) Confidence 0.31 Published 2008 Journal Journal of Korean Medical Science Section Body Doc Link PMC2580015 Disease Relevance 0.22 Pain Relevance 0
However, most patients with tuberculous meningitis had clearly an increased IgE index suggesting a local biosynthesis, but we failed to detect any IgE antibody activity against purified protein derivatives.
Positive_regulation (increased) of IgE Binding (index) of associated with mycobacterial infection
4) Confidence 0.26 Published 1984 Journal J. Neuroimmunol. Section Abstract Doc Link 6746896 Disease Relevance 0.35 Pain Relevance 0.16
Typically, mast cell activation occurs in response to cross-linkage of the high affinity IgE receptor (Fc?
Positive_regulation (response) of IgE Binding (linkage) of in mast cell
5) Confidence 0.07 Published 2004 Journal BMC Immunol Section Body Doc Link PMC521685 Disease Relevance 0.74 Pain Relevance 0.30
Pulmonary edema in fatal heroin overdose: immunohistological investigations with IgE, collagen IV and laminin - no increase of defects of alveolar-capillary membranes.
Neg (no) Positive_regulation (increase) of IgE Neg (no) Binding (investigations) of in capillary associated with cva and opiate addiction
6) Confidence 0.07 Published 2000 Journal Forensic Sci. Int. Section Title Doc Link 10808097 Disease Relevance 0.86 Pain Relevance 0.26
Theoretically, the more IgE production, the more IgE molecules bind on the surface of mast cells, thus the more intensive reaction of the mast cells can be in response to specific antigen challenge, the more inflammatory mediators to be released from the mast cells that cause more intensive reaction in antigen skin test.
Positive_regulation (mediators) of IgE Binding (bind) of in mast cells associated with inflammatory mediators
7) Confidence 0.06 Published 2006 Journal Clin Mol Allergy Section Body Doc Link PMC1524974 Disease Relevance 0.88 Pain Relevance 0.10

General Comments

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