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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.11
Pain Relevance 1.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (NGF, NTRK1) cell differentiation (NTRK1) signal transduction (NGF)
extracellular space (NGF) extracellular region (NGF) plasma membrane (NTRK1)
NGF (Homo sapiens)
NTRK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 23 100.00 Very High Very High Very High
antagonist 14 99.30 Very High Very High Very High
Neuronal excitability 1 96.64 Very High Very High Very High
Lasting pain 22 96.12 Very High Very High Very High
Hyperalgesia 10 90.36 High High
headache 1 86.88 High High
Arthritis 3 85.52 High High
Pain 88 80.52 Quite High
Osteoarthritis 45 74.24 Quite High
bradykinin 6 71.48 Quite High
Disease Link Frequency Relevance Heat
Pain 118 96.12 Very High Very High Very High
Hyperalgesia 11 90.36 High High
Headache 1 86.88 High High
Cystitis 1 85.92 High High
Arthritis 4 85.52 High High
Intraoperative Complications 1 83.28 Quite High
Injury 10 82.60 Quite High
Frailty 48 74.24 Quite High
Neuropathic Pain 20 58.84 Quite High
Nociception 9 58.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only a few small molecule NGF antagonists are available, but ALE0540, which inhibits the binding of NGF to TrkA and p75, and PD90780, which inhibits NGF binding to p75, have been proposed to have efficacy in chronic pain models [154,155].
Negative_regulation (inhibits) of NGF Binding (binding) of TrkA associated with nerve growth factor, lasting pain and antagonist
1) Confidence 0.08 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.11 Pain Relevance 1.39

General Comments

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