INT220061

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Context Info
Confidence 0.15
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.70
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (TRPV1) transport (TRPV1) plasma membrane (TRPV1)
lipid metabolic process (TRPV1)
Anatomy Link Frequency
synovial fluid 2
TRPV1 (Homo sapiens)
TRPA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 176 99.16 Very High Very High Very High
qutenza 14 99.16 Very High Very High Very High
Inflammatory mediators 10 96.92 Very High Very High Very High
TRP channel 6 96.36 Very High Very High Very High
bradykinin 12 95.56 Very High Very High Very High
Hyperalgesia 20 95.32 Very High Very High Very High
burning pain 4 91.36 High High
antagonist 28 86.16 High High
IPN 14 68.88 Quite High
agonist 22 60.64 Quite High
Disease Link Frequency Relevance Heat
Pain 236 99.16 Very High Very High Very High
INFLAMMATION 80 96.92 Very High Very High Very High
Hyperalgesia 22 95.32 Very High Very High Very High
Osteoarthritis 2 93.56 High High
Inflammatory Pain 14 68.88 Quite High
Shock 2 67.44 Quite High
Frailty 96 58.24 Quite High
Arthritis 8 50.00 Quite Low
Injury 20 34.96 Quite Low
Neuropathic Pain 40 20.20 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Thus, TRPA1 (ANKTM1) is co-localized with TRPV1 and is activated by capsaicin and mustard oil but can also be sensitized by inflammatory mediators, including bradykinin, known to be significantly elevated in osteoarthritic synovial fluid, to produce cold-induced burning pain [102].
TRPV1 Binding (localized) of TRPA1 in synovial fluid associated with inflammatory mediators, qutenza, osteoarthritis, bradykinin and burning pain
1) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.85 Pain Relevance 1.35
Thus, TRPA1 (ANKTM1) is co-localized with TRPV1 and is activated by capsaicin and mustard oil but can also be sensitized by inflammatory mediators, including bradykinin, known to be significantly elevated in osteoarthritic synovial fluid, to produce cold-induced burning pain [102].
TRPV1 Binding (localized) of ANKTM1 in synovial fluid associated with inflammatory mediators, qutenza, osteoarthritis, bradykinin and burning pain
2) Confidence 0.15 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 0.85 Pain Relevance 1.34

General Comments

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