INT220062

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 2.21
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (NGF, TNFRSF1B) endosome (NGF) signal transduction (NGF)
extracellular space (NGF) cell death (TNFRSF1B) plasma membrane (TNFRSF1B)
NGF (Homo sapiens)
TNFRSF1B (Homo sapiens)
Pain Link Frequency Relevance Heat
Nerve growth factor 46 100.00 Very High Very High Very High
antagonist 28 99.04 Very High Very High Very High
Lasting pain 44 98.36 Very High Very High Very High
Neuronal excitability 2 96.12 Very High Very High Very High
Hyperalgesia 20 89.84 High High
headache 2 86.36 High High
Arthritis 6 85.00 Quite High
Pain 176 81.12 Quite High
Osteoarthritis 90 78.72 Quite High
bradykinin 12 70.96 Quite High
Disease Link Frequency Relevance Heat
Pain 236 98.36 Very High Very High Very High
Hyperalgesia 22 89.84 High High
Headache 2 86.36 High High
Cystitis 2 85.40 High High
Arthritis 8 85.00 Quite High
Intraoperative Complications 2 82.76 Quite High
Injury 20 82.08 Quite High
Frailty 96 78.72 Quite High
Nociception 18 61.44 Quite High
Neuropathic Pain 40 58.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Only a few small molecule NGF antagonists are available, but ALE0540, which inhibits the binding of NGF to TrkA and p75, and PD90780, which inhibits NGF binding to p75, have been proposed to have efficacy in chronic pain models [154,155].
NGF Binding (binding) of p75 associated with nerve growth factor, lasting pain and antagonist
1) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.10 Pain Relevance 1.42
Only a few small molecule NGF antagonists are available, but ALE0540, which inhibits the binding of NGF to TrkA and p75, and PD90780, which inhibits NGF binding to p75, have been proposed to have efficacy in chronic pain models [154,155].
NGF Binding (binding) of p75 associated with nerve growth factor, lasting pain and antagonist
2) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.10 Pain Relevance 1.39

General Comments

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