INT220075

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Context Info
Confidence 0.11
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.36
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRM3) signal transducer activity (GRM3)
Anatomy Link Frequency
spinal 1
GRM3 (Homo sapiens)
Pain Link Frequency Relevance Heat
spinal dorsal horn 2 99.68 Very High Very High Very High
Pain 88 97.42 Very High Very High Very High
agonist 11 91.48 High High
Inflammation 32 90.08 High High
Hyperalgesia 10 89.56 High High
allodynia 8 88.44 High High
antagonist 14 85.84 High High
Lasting pain 22 80.56 Quite High
TRP channel 3 51.76 Quite High
nMDA receptor 2 51.52 Quite High
Disease Link Frequency Relevance Heat
Injury 10 97.76 Very High Very High Very High
Pain 118 97.42 Very High Very High Very High
INFLAMMATION 40 90.08 High High
Hyperalgesia 11 89.56 High High
Neuropathic Pain 20 88.44 High High
Nociception 9 72.68 Quite High
Stroke 1 65.04 Quite High
Frailty 48 50.00 Quite Low
Arthritis 4 50.00 Quite Low
Ataxia 1 23.92 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Metabotropic group II receptors (mGluR2 and mGluR3) also modulate pain transmission. mGluR2 is located in sensory neurones and presynaptic nerve terminals whereas mGluR3 is found all over the brain. mGluR3 can be selectively increased in the spinal dorsal horn neurones after peripheral UV injury [94]. mGluR2/3 receptor activation appears necessary to reduce nerve terminal excitability and to modulate pain transmission since treatment with the agonist L-acetyl carnitine reduced inflammatory hyperalgesia and mechanical allodynia and increased the expression of mGluR2/3.
Positive_regulation (increased) of mGluR3 in spinal associated with pain, hyperalgesia, allodynia, inflammation, spinal dorsal horn, injury and agonist
1) Confidence 0.11 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206352 Disease Relevance 1.36 Pain Relevance 1.28

General Comments

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