INT220082

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Context Info
Confidence 0.04
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (MMRN1) cell adhesion (MMRN1)
Anatomy Link Frequency
ECM 2
MMRN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 20 99.76 Very High Very High Very High
metalloproteinase 61 98.68 Very High Very High Very High
cytokine 8 96.40 Very High Very High Very High
rheumatoid arthritis 11 93.72 High High
Osteoarthritis 16 93.48 High High
Arthritis 1 75.92 Quite High
antagonist 3 47.44 Quite Low
Inflammatory response 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 27 99.76 Very High Very High Very High
Arthritis 5 94.88 High High
Rheumatoid Arthritis 11 93.72 High High
Osteoarthritis 23 93.48 High High
Disease 8 93.04 High High
Injury 16 89.64 High High
Cancer 15 76.88 Quite High
Stress 7 72.24 Quite High
Pressure And Volume Under Development 2 64.08 Quite High
Apoptosis 32 59.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The involvement of the regulated degradation of extracellular matrix (ECM) is essential for the physiological remodeling processes like tissue repair, development, and morphogenesis.
Regulation (regulated) of Protein_catabolism (degradation) of ECM in ECM
1) Confidence 0.04 Published 2010 Journal Biochemistry Research International Section Body Doc Link PMC3004377 Disease Relevance 0.26 Pain Relevance 0.34
, have direct and indirect pro-inflammatory effects to regulate the degradation of ECM components by stimulating secretion of proteolytic enzymes and other mediators, such as MMPs, aggrecanases and other members of the 'a disintegrin and metallo-proteinase with thrombospondin motifs' (ADAMTS) gene family, NO, and prostaglandin E2 [149,177,178].
Regulation (regulate) of Protein_catabolism (degradation) of ECM associated with inflammation
2) Confidence 0.03 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206353 Disease Relevance 0.97 Pain Relevance 0.31

General Comments

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