INT220088

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 4.04
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (CDKN2A) DNA binding (CDKN2A) protein complex (CDKN2A)
cytoplasm (CDKN2A) cytosol (CDKN2A) nucleolus (CDKN2A)
Anatomy Link Frequency
telomere 2
CDKN2A (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 49 96.00 Very High Very High Very High
Pain 2 79.96 Quite High
cytokine 16 68.00 Quite High
backache 22 5.00 Very Low Very Low Very Low
metalloproteinase 10 5.00 Very Low Very Low Very Low
Inflammation 6 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
palliative 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hyperplasia 3 99.52 Very High Very High Very High
Aging 186 98.84 Very High Very High Very High
Stomach Cancer 54 97.98 Very High Very High Very High
Apoptosis 8 96.88 Very High Very High Very High
Osteoarthritis 51 96.00 Very High Very High Very High
Intervertebral Disk Degeneration 24 95.08 Very High Very High Very High
Metastasis 19 94.04 High High
Cancer 55 89.16 High High
Pain 2 79.96 Quite High
Osteophyte 5 76.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
-galactosidase activity [12], increase in reactive oxygen species (ROS), telomere attrition [13] and p53/p16ink4 accumulation [11].
Positive_regulation (increase) of Positive_regulation (accumulation) of p16ink4 in telomere
1) Confidence 0.49 Published 2010 Journal The Open Rheumatology Journal Section Body Doc Link PMC2845788 Disease Relevance 1.61 Pain Relevance 0.38
In particular, we have found that telomeric erosion increases with age together with increased levels of p16INK4a.
Positive_regulation (increases) of Positive_regulation (increased) of p16INK4a
2) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.81 Pain Relevance 0
Here, we demonstrate for the first time that, in cells extracted from human NP tissue, increased levels of p16INK4a were associated with increased gene expression of the degradative enzymes MMP-13 and ADAMTS 5, which is characteristic of disc degeneration [5,39].
Positive_regulation (increased) of Positive_regulation (levels) of p16INK4a associated with intervertebral disk degeneration
3) Confidence 0.46 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206356 Disease Relevance 0.34 Pain Relevance 0.06
Knockdown of CBX7 expression in gastric cancer cells led to increased cellular senescence, decreased cellular proliferation and migration ability, accompanied by upregulation of p16(INK4a).


Positive_regulation (accompanied) of Positive_regulation (upregulation) of p16 associated with aging, hyperplasia and stomach cancer
4) Confidence 0.46 Published 2010 Journal J Exp Clin Cancer Res Section Abstract Doc Link PMC2933612 Disease Relevance 1.29 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox