INT220145

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Context Info
Confidence 0.01
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.92
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HPSE, CRH) carbohydrate metabolic process (HPSE) response to stress (CRH)
signal transduction (CRH) extracellular space (CRH) hydrolase activity, acting on glycosyl bonds (HPSE)
HPSE (Homo sapiens)
CRH (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 97.52 Very High Very High Very High
cytokine 16 95.56 Very High Very High Very High
Inflammation 9 89.64 High High
corticosteroid 1 84.48 Quite High
Inflammatory response 1 40.36 Quite Low
methotrexate 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 77 97.52 Very High Very High Very High
INFLAMMATION 11 89.64 High High
Obesity 14 5.00 Very Low Very Low Very Low
Disease 9 5.00 Very Low Very Low Very Low
Appetite Loss 8 5.00 Very Low Very Low Very Low
Renal Disease 4 5.00 Very Low Very Low Very Low
Disorder Of Lipid Metabolism 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Glucocorticoids exert negative feedback control on the HPA axis by suppressing hypothalamic CRH production and ACTH secretion.
HPA Negative_regulation (suppressing) of Gene_expression (production) of CRH
1) Confidence 0.01 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.92 Pain Relevance 0.64

General Comments

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