INT220146

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Context Info
Confidence 0.10
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.57
Pain Relevance 0.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (IGF1, IGFBP1) extracellular space (IGF1, IGFBP1) extracellular region (IGF1, IGFBP1)
Anatomy Link Frequency
liver 1
IGF1 (Homo sapiens)
IGFBP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 77 90.96 High High
Bioavailability 4 89.68 High High
cytokine 16 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
alcohol 4 5.00 Very Low Very Low Very Low
methotrexate 2 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 15 98.28 Very High Very High Very High
Apoptosis 68 96.64 Very High Very High Very High
Rheumatoid Arthritis 77 90.96 High High
Colon Cancer 15 87.48 High High
Obesity 18 76.64 Quite High
Adenoma 47 75.44 Quite High
Disease 10 71.16 Quite High
Stomach Cancer 1 41.28 Quite Low
Reprotox - General 1 2 39.44 Quite Low
Malignant Neoplastic Disease 5 29.60 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
IGF-binding protein-3 (IGFBP-3) is major IGF binding protein and is thought to exert a protective effect through modulation of IGF-I bioactivity as well as through IGF-I independent effects on cell proliferation and apoptosis [36].
IGF-I Binding (modulation) of IGF binding protein associated with apoptosis
1) Confidence 0.10 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2409350 Disease Relevance 1.01 Pain Relevance 0.04
IGFBP-1, which is also derived from the liver, binds to free IGF-I and is negatively regulated by nutrition and insulin [20].
IGF-I Binding (binds) of IGFBP-1 in liver
2) Confidence 0.07 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206381 Disease Relevance 0.55 Pain Relevance 0.15

General Comments

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